Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

Inclusion criteria

• Male or female between 21 and 65 years of age at screening
• Clinical diagnosis of drug-resistant epilepsy with on average, 4 or more seizures per month.
• Able to provide informed consent (or assent when applicable) by the subject or subject's legal representative.
• Be willing to undergo a brain MRI.
• Be able and willing to wear a headband during the treatment duration.
• Be able to complete scheduled visits and daily seizure logs.

Exclusion criteria

• Has a craniotomy or pathologic intracranial lesion (e.g. vascular malformations) in the trajectory of the focused ultrasound beam.
• Pregnant, breastfeeding, is attempting pregnancy, or unwilling to practice birth control during participation in the study.
• Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
• Has any unstable medical or psychiatric disease.
• Any contraindications for completing a brain MRI scan.
• Has evidence of any other clinically relevant neurological disorder at the time of screening, including Alzheimer's disease, frontotemporal dementia, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.