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OpenTrials
Completed

NCT Number: NCT00281346

Non-invasive Diagnosis of Coronary Artery Stenoses by Doppler Echocardiography

Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.

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Key information

Conditions

Stable Angina Pectoris Acute Myocardial Infarction Angina Pectoris Angina, Stable Angina, Unstable Cardiovascular Diseases Chest Pain Coronary Disease Coronary Stenosis Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Unstable Angina Pectoris Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ålesund Hospital HF

Ålesund, N-6026, Norway

About this study

Transthoracic Doppler echocardiographic evaluation with extensive evaluation of coronary stenoses in all 3 main branches using colour flow, pulsed Doppler and Coronary flow velocity reserve (CFVR)after pharmacologic stress with adenosin in the area of LAD and RDP. Blinded evaluation of Doppler results and coronary angiography regarding the other examination modality. Coronary angiography diagnostic "gold standard". Only stable and unstable patients otherwise scheduled for angiography on clinical reasons will be examined and included in the study.

Added January 2007 after ethics committee approval: comparison of CFVR with invasive fractional flow reserve (FFR) in selected subset of patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • unstable angina or acute myocardial infarction, or stable angina pectoris and
  • scheduled for coronary angiography on accepted clinical reasons

Exclusion criteria

  • past coronary artery grafting

Treatment and study plan

Doppler echocardiography

Procedure

Echocardiography

Primary outcomes

  1. Diagnostic yield: Accuracy, positive and negative predictive value.

    Time frame: Inhospital

  2. pr patient evaluation

    Time frame: Inhospital

Secondary outcomes

  1. pr stenosis evaluation

    Time frame: Inhospital

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Registry information

Official study title

Non-invasive Evaluation of Coronary Pathology by Transthoracic Doppler Echocardiography. A Comparative Study to Coronary Angiography.

Important dates

Study start
2005
Primary completion
2008
Study completion
2008
First posted
Jan 24, 2006
Registry last updated
Jul 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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