Maastricht University Medical Center
Maastricht, Limburg, 6229 HV, Netherlands
Location status: Recruiting
Recruiting
NCT Number: NCT03019471
Non Invasive Cancer Test (NICT): a Proof of Principle Study.
The investigators aim to collect tumor DNA out of blood of cancer patients. If this is successful this could lead to the development of a cancer test in blood in the future, which is less invasive than current diagnostic methods.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patients with newly diagnosed local or metastatic breast cancer, colorectal cancer, non-small cell lung cancer and anaplastic glioblastoma, before start of radiation therapy, chemoradiation or chemotherapy.
- Patients age > 18 years, willing and able to comply with the protocol as judged by the investigator with a signed informed consent
Exclusion criteria
- Patients with a history of malignant disease other than the disease under study, with an exception for adequately treated squamous cell carcinoma of the skin, basal cell carcinoma of the skin and in situ cervix carcinoma.
- Pregnancy
Treatment and study plan
Isolation of tumor DNA
GeneticPrimary outcomes
-
ctDNA
Time frame: One year
Demonstrate the presence or absence of ctDNA in patients plasma. Examine if there us a sufficient concentration of ctDNA in the plasma to reliably diagnose cancer and determine the CNV
Study contacts
Contact information is provided by the study sponsor or research team.
Job J. Verdonschot, Drs.
CONTACT
Merryn M. Macville, Dr.
CONTACT
Sponsors and collaborators
Lead sponsor
Maastricht University Medical Center
Other
Registry information
Acronym: NICT-NIPT-CA
Important dates
- Study start
- 2016
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Jan 12, 2017
- Registry last updated
- Oct 7, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.