The Hong Kong Polytechnic University
Hong Kong
NCT Number: NCT04780230
The proposed study aims to determine if transcranial direct current stimulation can enhance the effect of speech therapy in post-stroke patients with dysarthria.
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Notify Me18 year–75 year
All sexes
Interventional
Not applicable
Hong Kong
A total of 60 Cantonese-speaking post-stroke patients who are suffering from dysarthria will be recruited and randomly divided into real tDCS and sham groups. All the participants will receive individualized speech therapy based on the results of their speech assessment.
For the real tDCS group, an anodal high-definition tDCS of 2 milliamperes (mA) lasting for 20 minutes will be delivered to the orofacial area of the primary motor cortex (SM1) during speech therapy. For the sham tDCS group, stimulation given during speech therapy will only last for 30 seconds in order to cause a similar sensation on the scalp as the real stimulation group. There will be a total of 10 daily sessions during a 2-week period.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
An anodal high-definition tDCS of 2 mA lasting for 20 minutes will be delivered to the orofacial area of the primary motor cortex (SM1) during speech therapy.
An anodal high-definition tDCS of 2 mA lasting for 30 seconds will be delivered to the orofacial area of the primary motor cortex (SM1) during speech therapy.
Time frame: Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment
All participants will be required to produce a sustained vowel /a/, repeat some syllables (i.e., /pa/, /ta/, /ka/ and /pataka/), read a standard Chinese paragraph and have a 1-2 mins conversation with the researcher.
Time frame: Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment
The Modified Communication Effectiveness Index (CETI-M) is a 10-item patient-reported measure of change in functional communication ability.
Time frame: Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment
The lip and tongue function during speech production will be traced real time and objectively using the 3D-Electromagnetic Articulography (EMA, AG501-system).
Time frame: Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment
Acoustic measurements will be obtained from both sustained vowel phonation and connected speech.
Time frame: Change Before and After tDCS Stimulation at immediately post-treatment, 1-month and 3-month post treatment
The Chinese version of The Quality of Life of the Dysarthric Speaker (QOL-DyS) questionnaire will be used to assess participants' subjective speech related quality of life.
The Hong Kong Polytechnic University
Other
Modulation of Primary Motor Cortex to Enhance Treatment of Dysarthria Post-stroke
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