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OpenTrials
Completed

NCT Number: NCT04680481

Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.

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Key information

Conditions

Working Memory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • the patient can consent for themselves;
  • the patient has or is scheduled for surgically implanted electrodes for the purposes of phase II epilepsy surgical evaluation;
  • age 18+ years old;

Exclusion criteria

  • diminished capacity to consent;

Treatment and study plan

Transcranial Alternating Current Stimulation

Device

Traveling wave transcranial alternating current stimulation will be applied at 4 Hz and 23 Hz over frontal and parietal brain areas in a randomized counterbalanced order.

Primary outcomes

  1. Electrophysiological outcomes

    Time frame: Immediate effect during stimulation

    Changes in spectral power and coherence of the local field potentials during transcranial electric stimulation relative to no stimulation periods.

  2. Working memory outcomes

    Time frame: Immediate effect during stimulation

    Changes in working memory performance as measured with the N-back task (quantified with d-prime) during stimulation.

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Collaborators

  • National Institute of Mental Health (NIMH)

Registry information

Official study title

Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain Networks

Important dates

Study start
2020
Primary completion
2025
Study completion
2025
First posted
Dec 23, 2020
Registry last updated
Dec 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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