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NCT Number: NCT07064967

Non-Helium Magnetoencephalography in Autism Spectrum Disorder

The goal of this observational study is to learn how brain activity in children with autism spectrum disorder (ASD) differs from typical developing children using magnetoencephalography (MEG).

The main questions this study aims to answer are:

Do children with ASD show different patterns of neural oscillation compared to typically developing children? Can MEG identify specific brain features that help ASD diagnosis?

Participants will undergo MEG scan in both resting and tasking state, and their brain activity will be analyzed for characteristic neural oscillations and connectivity patterns.

This study may help develop better tools for early ASD diagnosis.

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Key information

Conditions

Autism Spectrum Disorder (ASD) Autism Spectrum Disorder Child Development Disorders, Pervasive Mental Disorders Neurodevelopmental Disorders

Age range

6 year–12 year

Sex eligibility

Male

Study type

Observational

Primary location

Guangzhou Women and Children's medical center

Guangzhou, Guangdong, 511399, China

Location status: Recruiting

Location contact

Wenhao Zhou, Medical Doctor

CONTACT

[email protected]

+86-020-81886332

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Boys aged 6 to 12 years;
  • Diagnosis of Autism Spectrum Disorder meeting DSM-5 criteria;
  • Intelligence quotient (IQ) score > 70 (assessed via Wechsler Intelligence Scale for Children or other validated cognitive test);
  • Sufficient compliance to participate in MEG experiments.

Exclusion criteria

  • Comorbid neurological disorders, genetic syndromes, or severe developmental disabilities;
  • Metallic implants that may interfere with MEG signal acquisition;
  • Current use of antipsychotic medications or sedatives.

Treatment and study plan

Magnetoencephalography

Diagnostic Test

Participants will undergo magnetoencephalography scan in both resting and tasking state.

Primary outcomes

  1. Identification of Neural Oscillation Characteristics in Children with Autism Spectrum Disorder

    Time frame: Baseline assessment (single time point, within 1 week of enrollment).

    The primary outcome will measure group differences in neural oscillation features (e.g., spectral power and spatial distribution) across frequency bands (alpha, beta, gamma) between children with Autism Spectrum Disorder and typically developing children during resting-state and task-based conditions. Quantified using time-frequency analysis of magnetoencephalography data. Statistical analysis will include independent t-tests (or Mann-Whitney U tests for non-normally distributed data) with false discovery rate (FDR) correction, using SPSS version 27.0.

Study contacts

Contact information is provided by the study sponsor or research team.

Ye Song, Medical Doctor

CONTACT

[email protected]

+86-020-81886332

Sponsors and collaborators

Lead sponsor

Guangzhou Women and Children's Medical Center

Other

Collaborators

  • Beijing X-Magtech Technology Limited

Registry information

Official study title

Non-Helium Magnetoencephalography for Identifying Neurobiological Features and Functional Biomarkers in Children With Autism Spectrum Disorder: An Observational Cohort Study

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jul 15, 2025
Registry last updated
Jul 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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