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Completed

NCT Number: NCT02009917

Non- Essential Amino Acid Requirements and Metabolism in Humans

Protein is a major structural component of all cells in the body. The nutritional importance of protein is because of their amino acids. 9 are called essential and 11 are called non-essential, based on whether we need to get them from diet. This classification is based on studies done using older techniques. Recent studies suggest that these so called non-essential amino acids play important roles in our body's health. For the first time, this proposal defines an experimental design to examine non- essential amino acid/nitrogen requirements and metabolism in humans using the Indicator Amino Acid Oxidation (IAAO) technique.

The objective of the current study is to examine the application of IAAO technique to determine the non-essential amino acid/nitrogen requirement in adult humans.

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Key information

Conditions

Healthy Adult Males

Age range

20 year–40 year

Sex eligibility

Male

Study type

Observational

Primary location

Child and Family Research Institute

Vancouver, British Columbia, V5Z4H4, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 20-40 years of age
  • Male
  • Classified as normal body weight based on body mass index (BMI) 18.5-25kg/m2
  • Free of any concurrent illness

Exclusion criteria

  • Men not in good health or have a metabolic, neurological, genetic or immune disorder including diabetes and hypertension
  • Men who are classified as underweight(<18.5kg/m2), overweight(25-30kg/m2) or obese (>30kg/m2) using the BMI classification)
  • Men who are allergic to milk, eggs and egg protein

Treatment and study plan

Primary outcomes

  1. 13 Carbon dioxide production

    Time frame: 8 hours (1study day)

    Urine and breath samples will be collected to measure the rate of oxidation of expired breath and flux by enrichment of urine.

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • Ajinomoto Co., Inc.

Registry information

Official study title

Application of Indicator Amino Acid Oxidation Technique to Determine Non-essential Amino Acids/Nitrogen Requirements in Adult Humans

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Dec 12, 2013
Registry last updated
Jul 18, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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