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NCT Number: NCT01728597

Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols

One of the main problems in cardiac magnetic resonance (MR) investigations is the strong dependence of the achieved image quality on optimal settings of sequence parameters and anatomical and physiological situations and it is well known that the diagnostic impact of cardiac MR investigations crucially depends on the adaption of imaging protocols to patients' state and ability to cooperate.

The aim of the present study is the evaluation and optimization of various 1.5 Tesla and 3 Tesla cardiac MR investigation protocols without application of contrast agent as well as the acquisition of normal values for new cardiac MR images techniques:

* normal myocardial morphology: T1-, T2- and T2*-weighted imaging and acquisition of normal values of magnetic relaxation times (sequence- and protocol dependent), * normal cardiac function: systolic and diastolic function (sequence- and protocol dependent), * cardiac anatomy and coronary artery imaging: feasibility to evaluate length, diameter and blood flow (sequence- and protocol dependent), * normal blood flow topologies in the heart and the surrounding great vessels: 2D- and 3D blood flow imaging and evaluation techniques (sequence- and protocol dependent).

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Key information

Conditions

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical Unitersity Graz, Department of Radiology, Division of General Radiology

Graz, Styria, 8036, Austria

Location status: Recruiting

Location contact

Clemens Reiter, Dr.

SUB_INVESTIGATOR

Corina Kräuter, DI

SUB_INVESTIGATOR

Gert Reiter, PD DI Dr.

SUB_INVESTIGATOR

Michael Fuchsjäger, Prof. Dr.

CONTACT

[email protected]

+43-316-385 ext. 2411

Michael Fuchsjäger, Prof. Dr.

SUB_INVESTIGATOR

Ursula Reiter, PD DI Dr.

PRINCIPAL_INVESTIGATOR

Ursula Reiter, PhD

CONTACT

[email protected]

+43-316-385 ext. 83347

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No history of cardiac or pulmonary diseases
  • ability to give informed consent

Exclusion criteria

  • General MR exclusion criteria eg. patients with metal devices or other magnetic material in or on the subjects body which will be hazardous for MR investigation (e.g. heart pace-maker, brain aneurysm clip, nerve stimulators, electrodes, penile implants, coloured contact lenses, patch to deliver medications through the skin, any metal implants as rods, joints, plates, pins, screws, nails or clips, embolization coil, or any metal fragments or shrapnel in the body),
  • pregnancy,
  • claustrophobia.

Treatment and study plan

Primary outcomes

  1. cardiac volumes

    Time frame: up to 1 week

    volumes of cardiac chambers in the cardiac cycle [ml], sequence- and protocol dependent

  2. cardiac performance

    Time frame: up to 1 week

    ejection fraction of cardiac chambers [%], sequence- and protocol dependent

  3. cardiac muscle mass

    Time frame: up to 1 week

    systolic and end-diastolic mass of cardiac chambers [g], sequence- and protocol dependent

  4. coronary artery anatomy

    Time frame: up to 1 week

    length and diameter [mm], sequence-, and protocol dependent

  5. blood flow velocity

    Time frame: up to 1 week

    maximum, minimum and average velocity [cm/s], sequence-, and protocol dependent

  6. blood flow vorticity

    Time frame: up to 1 week

    number of vortices of blood flow in the heart and surrounding great vessels, sequence and protocol dependent

  7. blood flow timing

    Time frame: up to 1 week

    time points of characteristic blood flow patterns in the heart and surrounding great vessels in the cardiac cycle [ms], sequence-, and protocol dependent

  8. magnetic relaxation times

    Time frame: up to 1 week

    systolic and diastolic T1, T2, T2* [ms], sequence- and protocol dependent

Study contacts

Contact information is provided by the study sponsor or research team.

Michael Fuchsjäger, Prof. Dr.

CONTACT

[email protected]

+43-316-385 ext. 2411

Ursula Reiter, PhD

CONTACT

[email protected]

+43-316-385 ext. 83347

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Collaborators

  • Amt der Steiermärkischen Landesregierung, Abteilung 3

Registry information

Official study title

Optimization of Non-contrast Enhanced 1.5 Tesla and 3 Tesla Cardiac Magnetic Resonance Imaging Techniques and Acquisition of Normal Values

Acronym: CMR-TECH

Important dates

Study start
2011
Primary completion
2025
Study completion
2027
First posted
Nov 20, 2012
Registry last updated
Feb 12, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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