No Sedation Versus Daily Interruption of Sedation in Chronic Obstructive Pulmonary Disease Mechanically Ventilated Patients- A Prospective Study

this study is to compare no-sedation versus daily interruption of sedation (DIS) in Chronic obstructive pulmonary disease (COPD) patients receiving mechanical ventilation upon the ventilator-free days.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Chronic Obstructive Pulmonary Disease (COPD) Agnosia Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Sedation and Analgesia Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Benha University Hospitals

Banhā, Qalyubia Governorate, 13518, Egypt

Location status: Recruiting

Location contact

abeer abdelghany assistant lecturer, assistant lecturer

CONTACT

[email protected]

+201222928687

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients of both sex aged 18 years or older
The study will include 60 patients divided into 2 equal groups
Invasive mechanical ventilation
Patients with COPD patients (post-bronchodilator FEV1/FVC< 70, and under follow through the department outpatient clinic) exacerbation admitted to the ICU and required invasive mechanical ventilation were recruited.

Exclusion criteria

Allergy to sedative which will be used

renal or hepatic impairment
proven or suspected psychiatric or neurological impairment
pregnancy

Treatment and study plan

daily Interruption of Sedation

Behavioral

The patients will be managed by DIS. Richmond agitation and sedation score (RASS) will be used for monitoring the depth of sedation

Primary outcomes

Ventilator-free days

Time frame: from day-1 to day-28)

Ventilator-free days (Number of days from day-1 to day-28) on which the patient did not need assistance to his breathe.

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Aug 28, 2025
Registry last updated: Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting