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Completed

NCT Number: NCT02253329

NMES During the Day and Prior to Sleep

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and prior to sleep

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

65 year–85 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre +

Maastricht, Netherlands

About this study

In the present study, the effect of a bolus of intrinsically labeled milk directly after an hour of one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and immediately prior to sleep

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 65-85 years
  • Male
  • 18.5 ≤ BMI ≤ 30.0

Exclusion criteria

  • Type II diabetes
  • All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
  • Use of anticoagulants, blood diseases, allergy for lidocaine
  • Use of NSAIDs (non-steroidal anti-inflammatory drugs) and acetylsalicylic acid
  • Patients suffering from PKU (Phenylketonuria)
  • Presence of implantable cardioverter defibrillator and/or pacemaker
  • Performed regular resistance type exercise in the past 6 months
  • Use of any tools to assist during walking (cane/ crutches/ walker)
  • (Partial) foot/ leg amputation

Treatment and study plan

Dietary protein plus NMES during the day

Procedure

Neuromuscular electrical stimulation after a protein bolus, performed during the day

Dietary protein plus NMES prior to sleep

Procedure

Neuromuscular electrical stimulation after a protein bolus, performed prior to sleep

Primary outcomes

  1. Incorporation of stable isotope amino acids into skeletal muscle tissue

    Time frame: 4-8 hours in the postprandial phase

Secondary outcomes

  1. Plasma amino acid enrichment

    Time frame: 4-8 hours in the postprandial phase

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

The Effect of Neuromuscular Electrical Stimulation on Post-prandial Protein Accretion During the Day and Prior to Sleep

Acronym: ESPRO2

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Oct 1, 2014
Registry last updated
May 21, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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