NLR and Emergency Surgery

In the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (NLR) is an index that reflects the state of inflammation and oxidative stress. In the perioperative period, NLR has been described as a predictor for patients who will develop renal injury, ischemic stroke, and myocardial injury. Since preoperative inflammation is a predictor of morbidity and mortality in patients undergoing non-cardiac surgery, a retrospective analysis of the inflammatory status of patients undergoing surgery at the center is proposed.

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Key information

Conditions

Emergency Surgery

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Clínico de la Universidad de Chile

Santiago, Santiago Metropolitan, 8380456, Chile

About this study

A retrospective analysis of patients operated on at the Clinical Hospital of the University of Chile is proposed. The search will be conducted in the electronic medical records of all patients operated on between January and December 2021, with no exclusion criteria for this analysis. Demographic data, complications, length of hospital stay, and specific characteristics such as the need for mechanical ventilation, time spent in intermediate care units, and ICU as well as total hospitalization time will be recorded. For the purpose of this study, the preoperative complete blood count of the patients will be analyzed to search for hematological variables that reflect the state of preoperative systemic inflammation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Availability of complete blood count in electronic medical records of all patients operated on between January and December 2021

Exclusion criteria

None

Treatment and study plan

Primary outcomes

NLR

Time frame: Day of surgery

Preoperative neutrophil-to-lymphocyte ratio
Mortality

Time frame: 6 months after surgery

30 and 180 days mortality

Sponsors and collaborators

Lead sponsor

University of Chile

Other

Registry information

Official study title

Neutrophil-to-Lymphocyte Ratio and Mortality After Emergency Surgery

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2023
First posted: Aug 12, 2024
Registry last updated: Dec 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed