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Completed

NCT Number: NCT03749512

NLCR in Prediction of the Grade of Lung Tumor.

The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading.

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Key information

Conditions

Lung Neoplasm Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Samodzielny Publiczny Szpital Kliniczny nr 1

Zabrze, Silesian Voivodeship, 41-800, Poland

About this study

Lung cancer remains as one of the leading causes of death among oncology patients. Close connection between inflammation and pathogenesis of some neoplasms was determined in a number of studies. Some studies show promise that ratio of neutrophil to lymphocyte count (NLCR) may be recognized as a prognostic marker for several carcinomas: renal, lung and colorectal. The aim of the study is to assess whether the value of neutrophil-lymphocyte count ratio from the routine preoperative blood test may predict lung tumors' grading. During routine preoperative blood tests complete blood count is done and NLCR, WBC, neutrophil and lymphocyte count is noted. After the thoracic surgery intervention and histopathological examination grading of lung tumor is noted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • consecutive thoracic surgery patients with lung cancer grading confirmed by histopathology postoperatively
  • preoperative routine complete blood count analysis

Exclusion criteria

  • infectious disease
  • pregnancy
  • autoimmunologic disease
  • other known conditions or treatments that may influence the blood count (seropositivity for HIV, chemotherapy, and corticotherapy)

Treatment and study plan

Complete blood count

Diagnostic Test

During routine preoperative blood test complete blood count is taken.

Histopathological examination

Other

Routine postoperative histopathological examination of lung tumor.

Primary outcomes

  1. Neutrophil-lymphocyte count ratio

    Time frame: From October 1, 2014 to October 15, 2018

    Neutrophil-lymphocyte count ratio is measured during routine preoperative blood tests.

Secondary outcomes

  1. Neutrophil count

    Time frame: From October 1, 2014 to October 15, 2018

    Neutrophil count is measured during routine preoperative blood tests.

  2. Lymphocyte count

    Time frame: From October 1, 2014 to October 15, 2018

    Lymphocyte count is measured during routine preoperative blood tests.

  3. Leucocyte count

    Time frame: From October 1, 2014 to October 15, 2018

    Leucocyte count is measured during routine preoperative blood tests.

Sponsors and collaborators

Lead sponsor

Medical University of Silesia

Other

Registry information

Official study title

Preoperative Neutrophil-lymphocyte Count Ratio in Prediction of the Grade of Lung Tumor.

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Nov 21, 2018
Registry last updated
Nov 21, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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