NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients

The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory support.

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Key information

Conditions

Mechanical Ventilation Complication Acute Respiratory Distress Syndrome High-flow Oxygenation Lung Diseases Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases Weaning Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

City hospital # 1

Arkhangelsk, Arkhangelskaya oblast, 163000, Russia

About this study

HFNO (high-flow nasal oxygenation and NIV (non invasive ventilation) are to be randomly compared in the ARDS postextubation period.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ARDS

Exclusion criteria

Severe ICU-aquired weakness Severe COPD

Treatment and study plan

respiratory support

Device

High-flow nasal oxygenation

Other names: Oxygenation

Primary outcomes

Weaning failure

Time frame: 48 hrs

Weaning failure and re-intubation or recanulation

Sponsors and collaborators

Lead sponsor

Northern State Medical University

Other

Registry information

Official study title

Comparison of High Flow Oxygenation, Noninvasive Ventilation and Standard Oxygen Therapy in the Early Post-extubation Period in Patients With Acute Respiratory Distress Syndrome

Important dates

Study start: 2017
Primary completion: 2022
Study completion: 2022
First posted: Mar 27, 2024
Registry last updated: Mar 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed