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NCT Number: NCT06182956

NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases

The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in diffuse interstitial pneumonia.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ADIR Association

Rouen, 76000, France

Location contact

Antoine CUVELIER, MD, PHD

SUB_INVESTIGATOR

Christophe GIRAULT, MD

SUB_INVESTIGATOR

David DEBEAUMONT, MD

SUB_INVESTIGATOR

Elise ARTAUD-MACARI, MD

CONTACT

[email protected]

+33232885992

Gurvan LEBOUAR, MD

SUB_INVESTIGATOR

Pierre Alexandre ROGER, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 yrs
  • Hospitalization in intensive care unit
  • Acute exacerbation of a previously/presently documented diffuse (fibrotic) interstitial lung disease
  • Dyspnea majoration since at least 1 month
  • Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload
  • Hypoxemia requiring oxygen flows > 6 L/min

Exclusion criteria

  • Contraindication to noninvasive ventilation or high-flow oxygen therapy
  • Immediate indication to endotracheal intubation or hemodynamic assistance
  • Body mass index > 40
  • Presence of a pacemaker or an implantable defibrillator
  • Presence of cutaneous lesions where Pulmovista® belt should be placed
  • Moribund patient
  • Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
  • Protected adult patient (tutorship or curatorship)
  • Patient deprived of liberty by court or administrative decision
  • No possibility to install nasogastric tube
  • Endotracheal or tracheostomy tube requirement during the study
  • Hemodynamic assistance requirement during the study

Treatment and study plan

noninvasive mechanical ventilation

Device

Noninvasive mechanical ventilation is a respiratory technique which allows the administration of positive inspiratory and expiratory airway pressures in order to ventilate the lungs.

Nasal high-flow oxygen therapy

Device

Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen.

Continuous Positive Airway Pressure

Device

Continuous positive airway pressure is a respiratory technique which allows to maintain a constant positive airway pressure during inspiration and expiration.

Primary outcomes

  1. Pulmonary compliance

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of global pulmonary compliance (Cglob) under noninvasive ventilation (NIV) and high-flow oxygen therapy (HFO) during acute respiratory failure in diffuse interstitial pneumonia.

Secondary outcomes

  1. Pulmonary compliance

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of global pulmonary compliance (Cglob) under NIV and continuous positive airway pressure (CPAP) during acute respiratory failure in diffuse interstitial pneumonia.

  2. Pulmonary compliance

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of global pulmonary compliance (Cglob) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  3. Pulmonary compliance

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of global pulmonary compliance (Cglob) under HFO and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.

  4. Pulmonary compliance

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of global pulmonary compliance (Cglob) under NIV and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.

  5. Pulmonary compliance

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of global pulmonary compliance (Cglob) under CPAP and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.

  6. Tidal volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Tidal volume under CPAP and face mask oxygen therapy (FM) during acute respiratory failure in diffuse interstitial pneumonia.

  7. Tidal volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Tidal volume under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  8. Tidal volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Tidal volume under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  9. Tidal volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Tidal volume under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  10. Tidal volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Tidal volume under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  11. Tidal volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Tidal volume under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  12. end-expiratory lung volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of end-expiratory lung volume under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  13. end-expiratory lung volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of end-expiratory lung volume under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  14. end-expiratory lung volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of end-expiratory lung volume under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  15. end-expiratory lung volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of end-expiratory lung volume under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  16. end-expiratory lung volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of end-expiratory lung volume under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  17. end-expiratory lung volume

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of end-expiratory lung volume under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  18. transpulmonary pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transpulmonary pressure under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  19. transpulmonary pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transpulmonary pressure under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  20. transpulmonary pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transpulmonary pressure under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  21. transpulmonary pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transpulmonary pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  22. transpulmonary pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transpulmonary pressure under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  23. transpulmonary pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transpulmonary pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  24. driving pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of driving pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  25. driving pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of driving pressure under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  26. driving pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of driving pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  27. driving pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of driving pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  28. driving pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of driving pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  29. driving pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of driving pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  30. Global inhomogeneity index

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Global inhomogeneity index under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  31. Global inhomogeneity index

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Global inhomogeneity index under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  32. Global inhomogeneity index

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Global inhomogeneity index under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  33. Global inhomogeneity index

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Global inhomogeneity index under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  34. Global inhomogeneity index

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Global inhomogeneity index under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  35. Global inhomogeneity index

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Global inhomogeneity index under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  36. respiratory rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of respiratory rate under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  37. respiratory rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of respiratory rate under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  38. respiratory rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of respiratory rate under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  39. respiratory rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of respiratory rate under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  40. respiratory rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of respiratory rate under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  41. respiratory rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of respiratory rate under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  42. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  43. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  44. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  45. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  46. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  47. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  48. inspiratory time

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of inspiratory time under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  49. oesophagal pressure swings

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  50. oesophagal pressure swings

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  51. oesophagal pressure swings

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure variations between inspiration and expiration under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  52. oesophagal pressure swings

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure variations between inspiration and expiration under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  53. oesophagal pressure swings

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure variations between inspiration and expiration under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  54. oesophagal pressure swings

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure variations between inspiration and expiration under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  55. transdiaphragmatic pressure variations

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  56. transdiaphragmatic pressure variations

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  57. transdiaphragmatic pressure variations

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure variations between inspiration and expiration under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  58. transdiaphragmatic pressure variations

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure variations between inspiration and expiration under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  59. transdiaphragmatic pressure variations

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure variations between inspiration and expiration under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  60. transdiaphragmatic pressure variations

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure variations between inspiration and expiration under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  61. transdiaphragmatic pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure time products under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  62. transdiaphragmatic pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure time products under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  63. transdiaphragmatic pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure time products under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  64. transdiaphragmatic pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure time products under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  65. transdiaphragmatic pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure time products under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  66. transdiaphragmatic pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transdiaphragmatic pressure time products under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  67. oesophagal pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure time products under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  68. oesophagal pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure time products under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  69. oesophagal pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure time products under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  70. oesophagal pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure time products under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  71. oesophagal pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure time products under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  72. oesophagal pressure time products

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of oesophagal pressure time products under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  73. ultrasound diaphragmatic strain.

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of ultrasound diaphragmatic strain under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  74. diaphragmatic thickening fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of diaphragmatic thickening fraction under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  75. diaphragmatic thickening fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of diaphragmatic thickening fraction under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  76. diaphragmatic thickening fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of diaphragmatic thickening fraction under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  77. diaphragmatic thickening fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of diaphragmatic thickening fraction under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  78. diaphragmatic thickening fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of diaphragmatic thickening fraction under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  79. diaphragmatic thickening fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of diaphragmatic thickening fraction under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  80. peak inspiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak inspiratory flow under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  81. peak inspiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak inspiratory flow under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  82. peak inspiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak inspiratory flow under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  83. peak inspiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak inspiratory flow under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  84. peak inspiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak inspiratory flow under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  85. peak inspiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak inspiratory flow under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  86. peak expiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak expiratory flow under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  87. peak expiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak expiratory flow under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  88. peak expiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak expiratory flow under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  89. peak expiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak expiratory flow under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  90. peak expiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak expiratory flow under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  91. peak expiratory flow

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of peak expiratory flow under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  92. Systolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Systolic arterial pressures under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  93. Systolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Systolic arterial pressures under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  94. Systolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Systolic arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  95. Systolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Systolic arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  96. Systolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Systolic arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  97. Systolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Systolic arterial pressures under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  98. Diastolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Diastolic arterial pressures under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  99. Diastolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Diastolic arterial pressures under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  100. Diastolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Diastolic arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  101. Diastolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Diastolic arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  102. Diastolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Diastolic arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  103. Diastolic arterial pressures

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Diastolic arterial pressures under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  104. Mean arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Mean arterial pressures under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  105. Mean arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Mean arterial pressures under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  106. Mean arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Mean arterial pressures under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  107. Mean arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Mean arterial pressures under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  108. Mean arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Mean arterial pressures under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  109. Mean arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Mean arterial pressures under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  110. systolic pulmonary arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of systolic pulmonary arterial pressure under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  111. systolic pulmonary arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of systolic pulmonary arterial pressure under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  112. systolic pulmonary arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of systolic pulmonary arterial pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  113. systolic pulmonary arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of systolic pulmonary arterial pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  114. systolic pulmonary arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of systolic pulmonary arterial pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  115. systolic pulmonary arterial pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of systolic pulmonary arterial pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  116. tricuspid annular plane systolic excursion

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of tricuspid annular plane systolic excursion under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  117. tricuspid annular plane systolic excursion

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of tricuspid annular plane systolic excursion under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  118. tricuspid annular plane systolic excursion

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of tricuspid annular plane systolic excursion under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  119. tricuspid annular plane systolic excursion

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of tricuspid annular plane systolic excursion under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  120. tricuspid annular plane systolic excursion

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of tricuspid annular plane systolic excursion under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  121. tricuspid annular plane systolic excursion

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of tricuspid annular plane systolic excursion under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  122. right ventricular strain

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right ventricular strain under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  123. right ventricular strain

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right ventricular strain under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  124. right ventricular strain

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right ventricular strain under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  125. right ventricular strain

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right ventricular strain under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  126. right ventricular strain

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right ventricular strain under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  127. right ventricular strain

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right ventricular strain under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  128. left ventricular ejection fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of left ventricular ejection fraction under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  129. left ventricular ejection fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of left ventricular ejection fraction under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  130. left ventricular ejection fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of left ventricular ejection fraction under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  131. left ventricular ejection fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of left ventricular ejection fraction under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  132. left ventricular ejection fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of left ventricular ejection fraction under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  133. left ventricular ejection fraction

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of left ventricular ejection fraction under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  134. E/E' ratio

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of E/E' ratio under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  135. E/E' ratio

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of E/E' ratio under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  136. E/E' ratio

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of E/E' ratio under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  137. E/E' ratio

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of E/E' ratio under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  138. E/E' ratio

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of E/E' ratio under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  139. E/E' ratio

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of E/E' ratio under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  140. right auricular pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right auricular pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  141. right auricular pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right auricular pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  142. right auricular pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right auricular pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  143. right auricular pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right auricular pressure under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  144. right auricular pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right auricular pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  145. right auricular pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of right auricular pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  146. cardiac output

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of cardiac output under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  147. cardiac output

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of cardiac output under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  148. cardiac output

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of cardiac output under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  149. cardiac output

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of cardiac output under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  150. cardiac output

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of cardiac output under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  151. cardiac output

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of cardiac output under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  152. heart rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of heart rate under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  153. heart rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of heart rate under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  154. heart rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of heart rate under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  155. heart rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of heart rate under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  156. heart rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of heart rate under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  157. heart rate

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of heart rate under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  158. Pulsed oxymetry

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of pulsed oxymetry under NIV and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  159. Pulsed oxymetry

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of pulsed oxymetry under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  160. Pulsed oxymetry

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of pulsed oxymetry under NIV and FM during acute respiratory failure in diffuse interstitial pneumonia.

  161. Pulsed oxymetry

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of pulsed oxymetry under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  162. Pulsed oxymetry

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of pulsed oxymetry under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  163. Pulsed oxymetry

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of pulsed oxymetry under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  164. transcutaneous carbon dioxide pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transcutaneous carbon dioxide pressure under CPAP and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  165. transcutaneous carbon dioxide pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transcutaneous carbon dioxide pressure under CPAP and FM during acute respiratory failure in diffuse interstitial pneumonia.

  166. transcutaneous carbon dioxide pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transcutaneous carbon dioxide pressure under CPAP and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  167. transcutaneous carbon dioxide pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transcutaneous carbon dioxide pressure under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  168. transcutaneous carbon dioxide pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transcutaneous carbon dioxide pressure under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  169. transcutaneous carbon dioxide pressure

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of transcutaneous carbon dioxide pressure under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  170. Dyspnea

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and FM during acute respiratory failure in diffuse interstitial pneumonia.

  171. Dyspnea

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  172. Dyspnea

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  173. Dyspnea

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  174. Dyspnea

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  175. Dyspnea

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Comparison of Borg's scale (from 0 to 10, 10 is maximal dyspnea) under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  176. Comparison of Comfort

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and NIV during acute respiratory failure in diffuse interstitial pneumonia.

  177. Comparison of Comfort

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and HFO during acute respiratory failure in diffuse interstitial pneumonia.

  178. Comparison of Comfort

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Visual comfort scale (from 0 to 10, 10 is maximal confort) under FM and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  179. Comparison of Comfort

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Visual comfort scale (from 0 to 10, 10 is maximal confort) under NIV and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  180. Comparison of Comfort

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Visual comfort scale (from 0 to 10, 10 is maximal confort) under HFO and CPAP during acute respiratory failure in diffuse interstitial pneumonia.

  181. Comparison of Comfort

    Time frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

    Visual comfort scale (from 0 to 10, 10 is maximal confort) under HFO and NIV during acute respiratory failure in diffuse interstitial pneumonia.

Study contacts

Contact information is provided by the study sponsor or research team.

Elise ARTAUD-MACARI, MD

CONTACT

[email protected]

+33232885992

Maryline LEFORT

CONTACT

[email protected]

+33232885992

Sponsors and collaborators

Lead sponsor

ADIR Association

Other

Registry information

Official study title

Evaluation of Physiological Effects of Noninvasive Mechanical Ventilation and High-flow Oxygen Therapy for Acute Exacerbations of Interstitial Lung Diseases

Acronym: IRAPIDPhysio

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Dec 27, 2023
Registry last updated
Dec 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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