NIR Fluorescence Imaging Technique in Thoracic Surgery With ICG

Lung cancer is a major threat to human health. Diagnosis and treatment using precision medicine is expected to be an effective method for preventing the initiation and progression of cancer. Although anatomical and functional imaging techniques such as radiography, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have played an important role for accurate preoperative diagnostics, for the most part these techniques cannot be applied intraoperatively. Optical molecular imaging is a promising technique that provides a high degree of sensitivity and specificity in tumor margin detection. Furthermore, existing clinical applications have proven that optical molecular imaging is a powerful intraoperative tool for guiding surgeons performing precision procedures, thus enabling radical resection and improved survival rates. However, detection depth limitation exists in optical molecular imaging methods and further breakthroughs from optical open surgery to minimally invasive intraoperative imaging methods are needed to develop more extensive and comprehensive intraoperative applications.

Inclusion criteria

• Pulmonary nodules undergoing thoracoscopy or thoracotomy
• Esophageal cancer patients who underwent radical surgery
• Preoperative liver function is normal
• No indocyanine green and iodine allergies, and indocyanine green skin test negative
• Volunteered to participate in this study and signed informed consent in this study

Exclusion criteria

• Preoperative liver dysfunction
• Indocyanine green or iodine allergies, or indocyanine green skin test positive
• Not combined with other well-controlled comorbidities
• Clinicians considered unsuitable for enrollment