Nicotine Vapor Specific Sensory Measurement

PRIMARY OBJECTIVE:

I. Study that flavors might be related to the phenomenon of 'indirect' toxicity.

OUTLINE: Participants are randomized to 1 of 2 conditions.

CONDITION I: Participants attend up to 3 video or telephone conferences over 2 hours each with a minimum of 24 hours and maximum of 1 week between sessions. Participants take a fixed number of puffs on 3 randomly assigned conditions (combinations of carrier and nicotine concentrations).

CONDITION II: Participants attend up to 2 video or telephone conferences over 2 hours each with a minimum of 24 hours and maximum of 1 week between sessions. Participants take a fixed number of puffs on a nicotine-free condition and 3 randomly assigned conditions (combinations of carrier concentration and nicotine form).

Inclusion criteria

• Current daily vapers of products containing nicotine
• No concurrent use of other tobacco products
• Self reported general good health
• No allergies - specifically known active untreated seasonal allergies that would interfere with smell or taste procedures
• No self-reported taste or smell deficits
• Not pregnant or lactating
• No medications known to interfere with taste/smell (i.e.: certain nasal sprays, nasal antihistamines, decongestants, antibiotics, medications containing zinc)
• Passing scores on the phenylthiocarbamine (PTC) and 6-n-propylthiouracil (PROP) smell and taste tests
• Access to video-conference or telephone
• Ability to store test products in a secure location away from children

Exclusion criteria

• Not current daily vapers
• Concurrent use of other tobacco products
• Self-reported fair or poor general health
• Allergies - active untreated seasonal allergies that would interfere with smell or taste procedures
• Self-reported taste or smell deficits
• Pregnant or lactating
• Medications known to interfere with taste/smell (i.e.: certain nasal sprays, nasal antihistamines, decongestants, antibiotics, medications containing zinc)
• Failing scores on the phenylthiocarbamine (PTC) and 6-n-propylthiouracil (PROP) smell and taste tests
• No access to video-conference or telephone
• Unable to store test products in a secure location away from children
• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Prisoners
• Adults unable to consent
• Adults unable to legally purchase tobacco products in New York (NY) state (18-20)