NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest

To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

Recruiting

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Key information

Conditions

Out-Of-Hospital Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases Nervous System Diseases Neurological Injury Trauma, Nervous System Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University medical center Maribor

Maribor, 2000, Slovenia

Location status: Recruiting

Location contact

Andrej Markota, MD, PhD

CONTACT

[email protected]

+38523212849

About this study

To investigate the serum levels of the light chain of NFL at different time points after ICU admission (12, 24, 30, 36, 42, 48 hours after ICU admission) patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU

Exclusion criteria

trauma, drowning, electrocution, less than 18 years of age,

Treatment and study plan

Primary outcomes

The difference in the dynamics of serum NFL levels measurements in patients with favorable neurological outcome compared to patients with non-favorable neurological outcome

Time frame: 3 years

NFL levels

Study contacts

Contact information is provided by the study sponsor or research team.

Matej Strnad, MD, PhD

CONTACT

[email protected]

+38651225448

Sponsors and collaborators

Lead sponsor

University Medical Centre Maribor

Other

Registry information

Official study title

Dynamics of Light Chain of NFL as a Predictor Factor of Neurological Outcome in Patients With Out of Hospital Cardiac Arrest

Important dates

Study start: 2022
Primary completion: 2026
Study completion: 2026
First posted: Feb 1, 2022
Registry last updated: Mar 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed