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Completed

NCT Number: NCT07081295

New Saline-contrast EIT Method Without Breath Hold by Low Pass Filter

The electrical impedance tomography (EIT) is a bedside, non-invasive, non-radiation imaging tool for lung mornitoring. Currently, the EIT saline-contrast method for lung perfusion evaluation has been widely used in clinical. However, this technique requires the patient to hold breath for 8-30s to avoid the respiratory interference. Hence, it is not suitable for patients that can not tolerate breath hold or unable to maintain a steady apnoea. This study aims to develop an algorithm system based on low frequency band pass filter for EIT saline-contrast lung perfusion estimation without ventilation interruption, and investigate the correlation and agreement of EIT results between the novel method and the conventional breath-hold method.

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Key information

Conditions

Lung Diseases Respiratory Tract Diseases

Age range

18 year–79 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • In need of lung perfusion assessment due to clinical condition
  • With central venous catheter

Exclusion criteria

  • Pregnant or breastfeeding females
  • contraindications to the use of EIT (automatic implantable cardioverter defibrillator, chest wounds limiting electrode belt placement, implantable pumps, etc.)
  • severe hyperchloremia (>155 mmol/L)
  • unable to tolerate breath-hold maneuver
  • edema disease (nephrotic syndrome, cirrhotic ascites, congestive heart failure, etc.)
  • Patients with severe hypernatraemia or hyperchloremia and severe hypertonicity
  • Hypertension (>160/100 mmHg), hypokalaemia (> 3.5 mmol/L)
  • Acute renal failure in oliguric stage, chronic renal failure with reduced urine output and poor response to diuretics

Treatment and study plan

Injection of hypertonic saline

Other

Injection 10 mL of 10% NaCl through central venous catheter

Primary outcomes

  1. Regional V/Q match

    Time frame: Offline analysis, immediately after the saline injection procedure

Secondary outcomes

  1. Pixel-wise lung perfusion fraction

    Time frame: Offline analysis, immediately after the saline injection procedure

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

A Novel Saline-contrast EIT Method for Lung Perfusion Estimation: Without Breath Hold by Low Frequency Band Pass Filter

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 23, 2025
Registry last updated
Jul 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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