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NCT Number: NCT03483337

New MRI Biomarkers in Head and Neck Cancers

Magnetic resonance imaging (MRI) is a diagnostic technique that takes pictures of organs of the body. It uses magnetic fields and radio waves that cannot be felt. This makes specific organs, blood vessels, or tumors easier to see. Diffusion MRI lets us measure the motion of water in the tumor.

The purpose of this study is to see if new MRI methods can give us more information about the tumor.

Recruiting

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Key information

Conditions

Head and Neck Cancer Disease Attributes Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Neoplasm Metastasis Neoplasms Neoplasms by Site Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Thyroid Cancer Thyroid Diseases Thyroid Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

Location status: Recruiting

Location contact

Alan Ho, MD, PhD

CONTACT

646-608-3774

Amita Dave, PhD

CONTACT

212-639-3184

Amita Dave, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Group 1 patients: Presence of a suspicious metastatic lesion or suspicious for recurrent disease in the head and neck region.
  • Group 2 patients:
  • Biopsy proven recurrent or metastatic or definitive head and neck cancer or (differentiated and undifferentiated) thyroid cancers in the head and neck region only.
  • Patients planning to undergo reatment at MSK

Exclusion criteria

  • Patient would require anesthesia for the study
  • Patients who are claustrophobic
  • Patients selecting treatment outside of MSK
  • Known reaction to Gd based contrast agent
  • Patients who have presence of a known contradiction to MRI
  • Pacemaker
  • Aneurysm clips
  • Patients with implants that are contradicted for MR imaging will be excluded
  • Pregnant
  • Age and mental status wherein he /she is unable to cooperate for MRI study

Treatment and study plan

MRI examinations

Other

Patients will be imaged on a 1.5 T or 3 T MR scanner either from GE or Philips. Patients will receive a test-retest scan in on session prior to start of treatment. Patients who will be receiving radiation therapy treatment at main campus, will also be imaged weekly during their course of treatment.

Primary outcomes

  1. For group 1: number of patients that have biomarkers that maybe early response to therapy indicators

    Time frame: 1 year

    The study is designed to determine if the MRI will provide quantitative imaging biomarkers to predict or assess early treatment response in R/M head and neck cancers. The MR data will be compared with clinical follow-up data. Additional sequence parameters.

  2. For group 2: number of patients response to treatment

    Time frame: 1 year

    will be assessed using ROC curves with RECIST with the RECIST version 1.1 response as the gold standard and change in DW-MRI and image feature metrics as predictors.

Study contacts

Contact information is provided by the study sponsor or research team.

Alan Ho, MD, PhD

CONTACT

646-608-3774

Amita Dave, PhD

CONTACT

[email protected]

212-639-3184

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Quantitative Imaging Tools to Derive DW-MRI Oncological Biomarkers

Important dates

Study start
2018
Primary completion
2027
Study completion
2027
First posted
Mar 30, 2018
Registry last updated
Apr 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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