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OpenTrials
Completed

NCT Number: NCT01275963

New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

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Key information

Conditions

Cardiovascular Pathology Cardiomyopathies Cardiovascular Diseases Heart Diseases Ventricular Dysfunction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Heidelberg

Heidelberg, 69120, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • persons of 18 years and older who receive a transthoracic echocardiography at our department
  • written consent

Exclusion criteria

  • permanent pacemaker rhythm
  • moderate/severe valvular heart disease

Treatment and study plan

Primary outcomes

  1. left ventricular longitudinal systolic strain (LV-LSS) in all patients

    Time frame: 2 years

    left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging

Secondary outcomes

  1. mitral annular plane systolic excursion (MAPSE) in all patients

    Time frame: 2 years

    MAPSE is measured by M-Mode echocardiography

  2. mitral annular systolic velocity (MASV) in all patients

    Time frame: 2 years

    MASV is derived from tissue doppler

  3. diastolic left ventricular function in all patients

    Time frame: 2 years

    Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression.

  4. pulmonary artery systolic pressure (PASP) in all patients

    Time frame: 2 years

    PASP is derived from Tricuspid valve regurgitation velocity

  5. left ventricular ejection fraction (LVEF) in all patients

    Time frame: 2 years

    EF is measured by modified Simpson's rule (biplane)

Sponsors and collaborators

Lead sponsor

Heidelberg University

Other

Registry information

Acronym: LAX

Important dates

Study start
2011
Primary completion
2016
Study completion
2016
First posted
Jan 13, 2011
Registry last updated
Nov 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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