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Active, Not Recruiting

NCT Number: NCT06663930

New Approach for Ovarian PRP Injection for Poor Responders

New Approach For Ovarian PRP Injection for poor responders

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Poor Responders

Age range

30 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Benha University

Banhā, benha, 13511, Egypt

About this study

Poor ovarian responders are at high risk of unsuccessful IVF/ICSI trials. In the last few years, many studies showed significant improvement of ovarian reserve parameters after PRP injection. There was no consensus regarding the route of injection, the volume injected, the location of PRP injection inside the ovary, the number of injection and the number of the cycle in which PRP is injected.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • AMH : < 0.5 ng/ml
  • FSH: > 10 miu but < 25 miu.
  • AFC : < 5 in both ovaries
  • Poor ovarian response, in a previous IVF/ICSI trial , resulting in 3 or fewer oocytes.
  • Normal uterine cavity , demonstrated by a recent hysteroscopy

Exclusion criteria

  • Primary ovarian insufficiency with FSH > 25 miu.
  • Previous ovarian surgery or Chemotherapy.
  • On going Anticoagulant use.
  • Carcinomas or a history of chronic pelvic pain.
  • Present infection.
  • Hemoglobin level lower than 11 g/L
  • platelet count lower than 150 x 10³/μL.

Treatment and study plan

Primary outcomes

  1. PRP effect on ovary for better fertility outcome

    Time frame: one year

    This is a prospective cohort clinical observational study. Aiming at evaluating the clinical effects of injecting PRP(Platelet Rich Plasma) into ovaries, of poor responders, taking all measures which may improve the response rate. That is why we will inject PRP for 2 consecutive cycles, the first cycle via laparoscopy and the next cycle, via ultrasonography.

Sponsors and collaborators

Lead sponsor

Bassem Ayman Mahmoud Assaf

Other

Registry information

Official study title

New Approach for Ovarian PRP Injection for Poor Responders ; Aiming At the Highest Response Rate

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Oct 29, 2024
Registry last updated
Oct 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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