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NCT Number: NCT07200817

Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

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Key information

Conditions

Neutrophils to Lymphocytes Intensive Care Unit Platelets Procalcitonin Prognostic Outcome Septic Patients Total Leucocytic Count

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain Shams University

Cairo, 11591, Egypt

Location status: Recruiting

Location contact

Bassem B Ghobrial, MD

SUB_INVESTIGATOR

Heba M Abdelrahman, MD

SUB_INVESTIGATOR

Manal M Shams, MD

SUB_INVESTIGATOR

Marwa M Salem, MD

SUB_INVESTIGATOR

Michael G Farag, Master

CONTACT

[email protected]

00201278142328

About this study

Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.

Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.

The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 18 to 70 years old.
  • Both sexes.
  • Septic patients (under the third international consensus definitions of sepsis and septic shock).

Exclusion criteria

  • Pregnancy
  • Malignancy
  • On immunosuppressive therapy
  • Hematological Disorders
  • Major Trauma
  • Major Burns
  • Child-Pugh Class C Liver Cirrhosis
  • On Hemodialysis

Treatment and study plan

Neutrophils to Lymphocytes and Platelets ratio (N/LP)

Diagnostic Test

The Neutrophils to Lymphocytes and Platelets ratio (N/LP) will be measured

Primary outcomes

  1. Levels of Neutrophils to Lymphocytes and Platelets ratio

    Time frame: 28 days post-procedure

    The ratio of neutrophils to Lymphocytes and Platelets in relation to 28-day mortality among septic patients will be recorded.

Secondary outcomes

  1. Procalcitonin (PCT)

    Time frame: 28 days post-procedure

    Procalcitonin (PCT) in relation to 28day mortality among septic patients will be recorded.

  2. Total Leukocytic Count (TLC)

    Time frame: 28 days post-procedure

    Total Leukocytic Count (TLC) in relation to 28day mortality among septic patients will be recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Michael G Farag, Master

CONTACT

[email protected]

00201278142328

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Comparison Between Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Oct 1, 2025
Registry last updated
Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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