Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) as an Inflammatory Markers to Predict Length of Hospital Stay After Total Laparoscopic Hysterectomy (TLH) for Benign Indications

Due to short hospital stay, rapid return to work, less pain, and good cosmetic results, laparoscopic hysterectomy ( LH) has substantially increased the era of hysterectomy procedures especially for the last two decades. The main reason for this is probably that LH leads to fewer inflammatory responses when compared to open abdominal hysterectomy. Although the inflammatory response is supposed to be lower with total laparoscopic hysteroscopy (TLH), unpredictable inflammatory response as a result of the operation has been still unenlightened and it can be associated with hospital stay.

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Key information

Conditions

Inflammation Hospital Stay Pathologic Processes Pathological Conditions, Signs and Symptoms Total Laparoscopic Hysterectomy

Sex eligibility

Female

Study type

Observational

About this study

IInflammatory response after surgery is an ordinary outcome which ends up with tissue repair. The increase in neutrophil levels accompanied with a decrease in lymphocyte levels is characteristic for the inflammatory response. Therefore, neutrophil to lymphocyte ratio (NLR) comes out as a simple index of inflammation. In the literature, NLR was shown not only to be associated with surgical complications but also the length of hospital stays in certain surgeries. Another inflammatory marker index of hemogram is the platelet to lymphocyte ratio (PLR). As a result of endothelial tissue damage, platelets are gathered in the affected area. Therefore, an increase in the number of platelets is inevitable for inflammation. Hence, PLR appears to be another simple index of inflammation due to the increase of platelets and the decrease of lymphocytes. PLR has also shown to be associated with length of hospital stay in various surgeries. NLR and PLR are both newly recommended inflammatory markers to estimate the prognosis of surgical treatment in clinics. Investigations regarding NLR and PLR concerning prognosis of patients after surgeries including gynecological cancer, cardiac surgeries, and emergency surgeries are available in prior literature. Investigators aimed to investigate the possible effects of inflammatory parameters, that can be easily obtained from complete blood count in the post-operative first day of total laparoscopic hysterectomy, to the length of hospital stay in patients without any complications.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients whom have undergone TLH

Exclusion criteria

Ureter injury
Bladder injury,
Bowel injury,
Superficial inferior mesenteric artery injury
Vaginal cuff hematoma
Vaginal cuff dehiscence
Endometriosis
Endometrial cancer
Cervical cancer
Chronic lymphocytic leukemia
Behçet disease
Electrolyte imbalance
Thyroid disease
Using anti-inflammatory medications
Having severe intraabdominal adhesions

Treatment and study plan

hemogram inflammatory parameters

Other

Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR)

Primary outcomes

Postoperative NLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.

Time frame: 4 years

NLR was calculated by dividing the absolute number of neutrophil to the absolute number of lymphocytes.
Postoperative PLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.

Time frame: 4 years

PLR were calculated by dividing the absolute number of platelets to the absolute number of lymphocytes.

Sponsors and collaborators

Lead sponsor

Gaziosmanpasa Research and Education Hospital

Other Gov

Registry information

Official study title

Can Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) be Used as Inflammatory Markers to Predict Length of Hospital Stay After Total Laparoscopic Hysterectomy (TLH) for Benign Indications?

Important dates

Study start: 2014
Primary completion: 2018
Study completion: 2018
First posted: Aug 12, 2021
Registry last updated: Aug 25, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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