Neutrophil to Lymphocyte Ratio and Postdural Headache

This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture headache (PDPH) in obstetric patients undergoing cesarean section under spinal anesthesia.

Recruiting

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Key information

Conditions

Preoperative Neutrophil-to-Lymphocyte Ratio (NLR) Brain Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Secondary Nervous System Diseases Post-Dural Puncture Headache Postdural Puncture Headache

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Istinye Üniversity

Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)

Location status: Recruiting

Location contact

ilke dolgun

CONTACT

[email protected]

ilke dolgun

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women aged 18 years or older
Underwent elective or emergency cesarean section under spinal anesthesia
Had complete preoperative complete blood count (CBC) data available
No known hematological or inflammatory disease
No intraoperative complications recorded
Medical records accessible for postoperative follow-up regarding PDPH symptoms

Exclusion criteria

Age under 18
Absence of preoperative complete blood count data
Presence of hematologic malignancy, active infection, autoimmune disease, or immunosuppressive therapy
Platelet count <150,000/mm³ or INR >1.5
Incomplete or missing medical records

Treatment and study plan

PDPH

Other

Observational analysis of preoperative inflammatory markers (e.g., NLR, PLR, SIRI) in relation to PDPH development following spinal anesthesia.

Primary outcomes

Postdural Puncture Headache (PDPH) incidence

Time frame: Within 10 days postoperatively

The occurrence of PDPH symptoms within 10 days following spinal anesthesia in obstetric patients, as documented in medical records.

Study contacts

Contact information is provided by the study sponsor or research team.

ilke dolgun

CONTACT

[email protected]

+905555485632

Sponsors and collaborators

Lead sponsor

Istinye University

Other

Registry information

Official study title

Preoperative Neutrophil-to-Lymphocyte Ratio as a Predictor of Post-Dural Puncture Headache Following Cesarean Section Under Spinal Anesthesia

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Jul 20, 2025
Registry last updated: Jul 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed