Chest Department -Faculty of Medicine
Alexandria, Egypt, 11511
Completed
NCT Number: NCT07003204
Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratios in Exudative Pleural Effusion
Exudative pleural effusion (EPE) presents a diagnostic challenge, requiring accurate biomarkers to predict outcomes and guide treatment. The neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) in pleural fluid are emerging as potential prognostic markers. We aimed to assess the diagnostic and prognostic utility of pleural fluid NLR and MLR in EPE.
Completed
Looking for future studies?
Notify MeKey information
Conditions
Age range
18 month and older
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
Pleural fluid NLR and MLR are reliable biomarkers for diagnosing malignant pleural effusion and predicting poorer survival outcomes. These ratios may be useful in clinical practice, especially in resource-limited settings, to guide decision-making in the management of pleural effusions.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- adult patients aged 18-80 years with an EPE diagnosis confirmed by thoracentesis.
Exclusion criteria
- Exclusion criteria included patients with a history of recent surgery, corticosteroid use, or those with mixed effusion types.
Treatment and study plan
Medical thoracoscopy
Procedurepleural fluid aspiration and cellular analysis
Primary outcomes
-
MLR and NLR measuring in pleural fluid
Time frame: 1 month
counting pleural fluid monocytes,lymphocytes and neutrophils
Other outcomes
-
MLR and NLR measuring in pleural fluid
Time frame: one month
counting the pleural monocytes, neutrophils and lymphoctes
Sponsors and collaborators
Lead sponsor
Alexandria University
Other
Registry information
Official study title
Diagnostic and Prognostic Role of Pleural Fluid Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratios in Exudative Pleural Effusion
Important dates
- Study start
- 2025
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Jun 4, 2025
- Registry last updated
- Jun 4, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.