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OpenTrials
Completed

NCT Number: NCT02916043

Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality

Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, 03080, South Korea

About this study

Acute kidney injury (AKI) after cardiovascular surgery remains a serious complication associated with increased mortality for up to 10 years. The incidence of AKI after cardiovascular surgery is as high as 55% and the incidence of renal replacement therapy (RRT) to be up to 8 %.

Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are associated with the postoperative acute kidney injury and long-term mortality after cardiovascular surgery using cardiopulmonary bypass.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients who underwent cardiovascular surgeries with cardiopulmonary bypass (CPB), including valve replacement and surgery on the thoracic aorta at the Seoul National University Hospital between 2007 and 2015

Exclusion criteria

  • Missing preoperative serum creatinine (sCr) values
  • Missing preoperative platelet, neutrophil and lymphocyte counts
  • Patients who underwent preoperative hemodialysis

Treatment and study plan

Cardiovascular surgery with cardiopulmonary bypass

Procedure

Patients who underwent cardiovascular surgery including valve replacement or thoracic aortic surgery with cardiopulmonary bypass

Primary outcomes

  1. Acute kidney injury

    Time frame: postoperative day seven

    acute kidney injury during postoperative seven days defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria

Secondary outcomes

  1. All-cause mortality

    Time frame: postoperative seven years

    all-cause mortality after cardiovascular surgery after postoperative seven years

Other outcomes

  1. Postoperative length of hospital stay

    Time frame: postoperative two month

    postoperative length of hospital stay

  2. Postoperative length of ICU stay

    Time frame: postoperative two months

    postoperative length of ICU stay during postoperative two months

  3. Postoperative incidence of complications

    Time frame: postoperative two months

    postoperative incidences of surgery-related complications during hospital stay

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Risk Factor of Acute Kidney Injury After Open Heart Surgery With Cardiopulmonary Bypass

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Sep 27, 2016
Registry last updated
Nov 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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