Neurotrophins Implications in Primary Sjögren Syndrome

2 supplementary blood sample for determination of seric and lymphocytic NT profile will be added to a standard biological analysis done for pSS follow- up.

Salivary sicca syndrome will be evaluated with un-stimulated salivary flow rate. Saliva fluid will be collected from NTs levels determination (ELISA). Ocular sicca syndrome will be evaluated by Schirmer tests and Lissaline green test. A conjunctival cytological impression will be done in order to determine NTs conjunctival production by flow cytometry.

Inclusion criteria

Arm : primary Sjögren syndrome:

• All patients must fulfill the revised criteria for primary Sjögren syndrome.
• Age of entry into the study ≥ 18 yrs.
• Affiliated or profit patient of a social security system.
• Informed consent signed up.

Arm : healthy volunteers:

• All patient free of autoimmune disease.
• Age of entry into the study ≥ 18 yrs.
• Affiliated or profit patient of a social security system.
• Informed consent signed up.

Exclusion criteria

• Patient with psychiatric disorders not related with antiphospholipid syndrome and / or cerebral complication of SGSp.
• Addictive behaviors (alcoholism, cocaine or opioid abuse).
• Patient with anti-depressive drugs.
• Patient with concurrent malignancy
• Pregnancy
• Patients under measure of maintenance of justice.
• Patients unable to understand or to participate to the study.
• Child and major patients making the object of a measure of lawful protection.
• Patients deprived of freedom.

Exclusion criteria

for control group

• Autoimmune disease.
• Steroid treatment (>20 mg/day).
• Immunosuppressive treatment.
• Concurrent malignancy.
• Concurrent psychiatric disorders.
• Anti-depressive drugs.
• Pregnancy.