Skip to main content
OpenTrials
Completed

NCT Number: NCT02880579

Neurothrombectomy France

The Ischemic Brain Vascular Accident (CVA) is a major public health issue. An Early and appropriate charging anyone with stroke is essential to reduce mortality, reduce dependency and promote recovery of autonomy. Intravenous fibrinolysis in patients with cerebral infarction (NINDS 1995), is reserved for a small proportion of highly selected patients. It therefore remains a significant therapeutic challenge, especially for patients with against-indications to fibrinolysis or in whom there is no immediate benefit. For twenty years of mechanical devices have been developed to remove, as quickly as possible, the cause of intracranial arterial occlusion and allow restoration of blood flow before brain damage is irreversible.

NTF The protocol is part of the evaluation process of our clinical practices recommended by the National Health Authority (HAS), in the specific context of mechanical thrombectomy performed in French centers of interventional neuroradiology working with neurovascular units (A V).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cerebral Artery Occlusion

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de Nantes

Nantes, 44093, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Signature of the information notice by the patient or his legal representative
  • Age> 18 years
  • Clinical and imaging consistent with ischemic stroke whose symptoms start back within 8h
  • Thrombosis (TICI 0 or 1) of the carotid T, M1, M1-M2 bifurcation of the basilar artery occlusion in TANDEM ACI / M1.

Exclusion criteria

  • Pregnant or lactating women
  • Rapid improvement of NIHSS (gain of more than 4 points) between two pre-treatment assessments.
  • ASPECT score <7 on the scanner or <5 on the diffusion-weighted imaging (DWI)
  • Intracranial hemorrhage on imaging
  • Inability of clinical evaluations at 3 months
  • extensive lesions of the brain stem (the presence of a complete section of the brainstem hyperintense b1000)
  • 0 Refusal to participate in the study

Treatment and study plan

Primary outcomes

  1. clinical score for handicap (mRS)

    Time frame: at 3 months

Secondary outcomes

  1. hemorrhagic complications on postoperative imaging

    Time frame: baseline

  2. hemorrhagic complications on postoperative imaging

    Time frame: at 1 day

  3. physiological parameter : age

    Time frame: baseline

    Factors of good clinical prognosis

  4. presence of coronary artery disease

    Time frame: baseline

    Factors of good clinical prognosis

  5. presence of arterial hypertension

    Time frame: baseline

    Factors of good clinical prognosis

  6. presence of diabetes

    Time frame: baseline

    Factors of good clinical prognosis

  7. presence of hypercholesterolemia

    Time frame: baseline

    Factors of good clinical prognosis

  8. presence of intracranial stenosis

    Time frame: baseline

    Factors of good clinical prognosis

  9. presence of occlusive arterial disease

    Time frame: baseline

    Factors of good clinical prognosis

  10. presence of haematological disorders

    Time frame: baseline

    Factors of good clinical prognosis

  11. presence of neoplasia

    Time frame: baseline

    Factors of good clinical prognosis

  12. NIHSS score

    Time frame: baseline

    Factors of good clinical prognosis

  13. ASPECTS score

    Time frame: baseline

    Factors of good clinical prognosis

  14. MRI imaging of stroke

    Time frame: baseline

    Factors of good clinical prognosis

  15. unblocking rate based on the score TICI

    Time frame: at 3 months

  16. NIHSS evaluation

    Time frame: at 24h

  17. Influence of collaterality score on the NIHSS

    Time frame: at 24h

  18. Influence ASPECTS score on the NIHSS

    Time frame: at 24h

  19. Influence ASPECTS score on the NIHSS

    Time frame: at 3months

  20. influence of anesthesia on the NIHSS

    Time frame: at 24h

  21. hemorrhagic complications

    Time frame: at 24h

  22. Influence of hemorrhagic complications on NIHSS

    Time frame: at 24h

  23. Influence of hemorrhagic complications on NIHSS

    Time frame: at 3 months

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Evaluation of Clinical Results of Treatment of Cerebral Artery Occlusion by Mechanical Thrombectomy, in the Acute Phase of Stroke

Acronym: NTF

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Aug 26, 2016
Registry last updated
Jun 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.