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NCT Number: NCT06688968

Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease

The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.

The main questions it aims to answer are:

1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects. 2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.

Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :

* A semi-structured interview to check the participants eligibility and gather demographic data. * Neuropsychological tests and questionnaires will then be administered. * A relative of the study participant will help complete questionnaires.

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Key information

Conditions

Alzheimer Disease, Early Onset Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Non Pharmacological Intervention Parkinsons Disease With Dementia Tauopathies

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Montpellier - CEPMo, Montpellier, Hérault, France

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About this study

Music therapy appears to be highly relevant as a Non-Medication Intervention in Alzheimer s (AD) and Parkinson s disease (PD). It is said to reduce depressive symptoms following music therapy sessions in dementia . With regard to Parkinson s disease, music therapy brings benefits in terms of motor skills, communication, breathing and emotional aspects. Reviews point to the need to differentiate beneficial effects according to different pathologies.

To date, no study has investigated the evolution of sensitivity to musical reward in AD. Furthermore, no study has discriminated the evolution of musical engagement in several neurodegenerative pathologies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

General inclusion criteria:

  • 60 years and older
  • French-speaking and volunteering for the study
  • Living at home with a relative

Alzheimer's disease inclusion criteria:

  • Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984)
  • MMSE greater than or equal to 20

Inclusion criteria

Parkinson's disease :

  • Diagnosis of Idiopathic Parkinson's disease
  • MMSE greater than or equal to 20

Exclusion criteria

  • No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes)
  • Autistic disorders
  • History of stroke or head trauma
  • Unstable medical condition (cancer)
  • Subject unable to read and/or write
  • Hearing impairment without hearing aids
  • Refusal of consent after information
  • Persons unable to give consent, research carried out in emergency situations, etc.)
  • Non-affiliation with a social security scheme
  • Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
  • Person under legal protection (guardianship, curatorship, legal protection)
  • Person participating in another research project with an exclusion period still in progress

Treatment and study plan

neuropsychologist interview

Behavioral

It will take place either at the hospital or at the participant's home.

This interview will consist of :

  • socio-demographic data collection
  • neuropsychological tests:
  • MMSE test (Mini Mental State Examination) cognitive function
  • RL-RI-16 test (16-item free recall/indexed recall test)
  • BECS test (Semantic knowledge assessment battery )
  • WCST test (Wisconsin Card Sorting Test )
  • Musical Cognition Test
  • Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire

Questionnaire

Behavioral

The participant answers questionnaires:

  • Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire)
  • Questionnaire BMRQ (Barcelona Reward Music Questionnaire)
  • Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale)
  • Questionnaire LARS (Lille's Apathy Rating Scale)
  • Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)

Primary outcomes

  1. Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults.

    Time frame: Baseline

    Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.

Secondary outcomes

  1. The comparison of self- and hetero-questionnaires will be carried out within each group for each MUseQ24 dimension

    Time frame: Baseline

    Compare the results of the self-reported and hetero-reported versions of the Musical Engagement Questionnaire.

    Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.

  2. Comparison of global cognition between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Mini Mental State Examination (MMSE) scoring from 0 (minimum) to 30 (maximum), with higher scores indicating better semantic memory function.

  3. Comparison of Executive Function between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Wisconsin Card Sorting Test (WCST) which assesses executive functioning globally with a rule deduction task. (Scoring from 0 to 6 for the number of correct categories and 0 to 48 for the number of mistakes). The higher the number of categories, the higher the executive functioning. The higher the number of errors, the lower the executive functioning.

  4. Comparison of Episodic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Free and Cued Recall Test (RL/RI-16), a 16 items tests scoring from 0 (minimum) to 48 (maximum), with higher scores indicating better memory recall.

  5. Comparison of Semantic Memory Function between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Recognition subtest of the Battery for the Assessment of Semantic Knowledge (BECS) scoring from 0 to 40.

    Higher scores indicate stronger semantic memory abilities, with lower scores reflecting potential deficits in semantic knowledge.

  6. Comparison of Musical Cognition between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Test of Orientation in Music Therapy (TOM), scoring from 0 to 34 Higher scores represent better musical cognition abilities, while lower scores may indicate reduced cognitive processing of musical information.

  7. Comparison of Semantic Musical Memory between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    The extension of the Test of Orientation in Music Therapy (TOM), scoring from 24 to 120.

    Higher scores represent better musical cognition abilities, while lower scores may indicate reduced cognitive processing of musical information.

  8. Comparison of Sensitivity to musical reward between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Barcelona Reward Music Questionnaire BRMQ, (scoring 20 to 100, the lower the score the lower the sensitivity to musical reward). It contains 20 items scored on a 5-point Likert scale. It contains 5 dimensions: musical search, emotional evocation, mood regulation, social reward and sensorimotor.

  9. Comparison of Self-assessed musical engagement between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    MusEQ-24, self-reported Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.

  10. Comparison of Memory recall during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    MusEQ-24 item 22, hetero-reported (scoring 0 to 5, the lower the score the lower memory recall)

  11. Comparison of emotional experience during music listening during music listening reward between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    MusEQ-24 Emotion subscale, hetero-reported (scoring 0 to 5, the lower the score the lower the emotional experience)

  12. Comparison of Hedonic function reward between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Snaith-Hamilton Pleasure Scale (SHAPS), a 14 items scale, Score Range: 0 (minimum) to 14 (maximum).

    Higher scores suggest anhedonia, with lower scores indicating a greater capacity for experiencing pleasure.

  13. Comparison of Affective blunting between Alzheimer's, Parkinson's and healthy elderly groups

    Time frame: Baseline

    Emotional intensity subscale of Lille's Apathy Rating Scale (LARS) a 33 items scale. The LARS is divided into 9 subscales, each scoring -4 to +4.

    Higher scores reflect greater affective blunting (reduced emotional intensity), while lower scores suggest a more typical range of emotional responses.

  14. Comparison of Depression symptoms

    Time frame: Baseline

    Patient Health Questionnaire 9 items (PHQ-9). Score Range: 0 (minimum) to 27 (maximum), each item is rated from 0 to 3 Score Interpretation: Higher scores indicate more severe depressive symptoms, with lower scores suggesting fewer depressive symptoms or none at all.

  15. Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Wisconsin Card Sorting Test (WCST) for each group

    Time frame: Baseline

    correlation coefficient R

  16. Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the 16-item free recall/indexed recall test (RL/RI- 16) for each group

    Time frame: Baseline

    correlation coefficient R

  17. Correlation between Barcelona Reward Music Questionnaire (BMRQ) and Lille's Apathy Rating Scale (LARS) subscale for each group

    Time frame: Baseline

    correlation coefficient R

  18. Correlation between the Barcelona Reward Music Questionnaire (BMRQ) and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group

    Time frame: Baseline

    correlation coefficient R

  19. Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Wisconsin Card Sorting Test (WCST) for each group

    Time frame: Baseline

    correlation coefficient R

  20. Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the 16-item free recall/indexed recall test (RL/RI- 16) for each group.

    Time frame: Baseline

    correlation coefficient R

  21. Correlation between the Emotion subscale of the MusEQ 24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group

    Time frame: Baseline

    correlation coefficient R

  22. Correlation between the Emotion Subscale of the MusEQ 24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group

    Time frame: Baseline

    correlation coefficient R

  23. Correlation between Item 22 of the MusEQ-24 hetero-reported version and Wisconsin Card Sorting Test (WCST) for each group

    Time frame: Baseline

    correlation coefficient R

  24. Correlation between item 22 of the MusEQ-24 hetero-reported version with 16-item free recall/indexed recall test (RL/RI- 16) for each group

    Time frame: Baseline

    correlation coefficient R

  25. Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Lille's Apathy Rating Scale (LARS) subscale for each group

    Time frame: Baseline

    correlation coefficient R

  26. Correlation between Item 22 of the MusEQ-24 hetero-reported version and the Snaith-Hamilton Pleasure Scale (SHAPS) for each group

    Time frame: Baseline

    correlation coefficient R

Study contacts

Contact information is provided by the study sponsor or research team.

KARIM BENNYS, MD

CONTACT

[email protected]

04.67.33.72.32 ext. + 33

Mikaël Genguelou, PhD

CONTACT

[email protected]

06.04.45.37.94. ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Collaborators

  • Laboratoire EPSYLON

Registry information

Official study title

Observational Pilot Study of Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease. What Are the Effects of Mnestic or Hedonic Impairment on Emotion, Reminiscence and Musical Enjoyment

Acronym: MUSENGAGE

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Nov 14, 2024
Registry last updated
Mar 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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