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NCT Number: NCT05481749

Neuropsychological Assessment Of The Oldest-Old Population.(NEUROPSIC-GR)

Neuropsychological tests currently considered to evaluate the cognitive performance of the oldest-old population (more than 80 years) are not adapted to this group population. This trial aims to determine the normal limits for this group population of a set of 18 neuropsychological test. Results may improve the diagnostic cognitive evaluation of this population.

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Key information

Age range

80 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centro de Salud Les Roquetes-Sant Pere de Ribes, Sant Pere de Ribes, Barcelona, Spain

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About this study

120 subjects more than 80y old (non-institutionalized) grouped in 4 age categories (80-84, 85-89, 90-94, 95 or more) will be evaluated through 18 neuropsychological tests (usually considered at Memory Clinics).

Subjects will be recruited from 5 Primary Care Centers by a random selection method (stratified by age group).

Normal limits will be defined by the percentiles of test punctuation. Previously, punctuation will be adjusted by age and education level by lineal regression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 80 or more years old
  • Residence at Comarca del Garraf
  • Able to be transfered to study center
  • Sufficient reading and writing capacity to carry out the neuropsychological tests, at the evaluator's discretion.

Exclusion criteria

  • Patient at end-of-life situation or with a very short life expectancy (days-weeks).
  • Hospital admission in the previous 3 months.
  • History of relevant mental illness: major depression, psychosis, bipolar disorder, obsessive-compulsive disorder.
  • Disease of the central nervous system with possible cognitive impairment: Parkinson's disease, multiple sclerosis, brain tumor, stroke with cognitive impairment, epilepsy, severe traumatic brain injury.
  • History of alcoholism or substance abuse.
  • Severe sensory deficit that prevents performing neuropsychological tests, at the discretion of the evaluator.
  • Positive Shortened Spanish Informant Questionnaire for Cognitive Decline in the Elderly questionnaire (SS-IQCODE) or Lobo's Cognitive Mini-examination Test (spanish adaptation of Minimental of Folstein test) with a score < 23 (20 in people with low schooling or illiteracy).
  • Dementia criteria according to the Diagnostic and Statistical Manual of Mental Disorders IV.

Treatment and study plan

Primary outcomes

  1. Cognitive Performance

    Time frame: This outcome will be evaluated at Memory Clinic Unit, following the enrollment visit. The evaluation of this outcome will last approximately 60 minutes.

    Cognitive performance will be evaluated by 18 neuropsychological test (quantitative scores) which cover all main cognitive domains (memory and learning, language, perceptual-motor abilities, executive functions and attention).

Study contacts

Contact information is provided by the study sponsor or research team.

César Gálvez-Barrón, Ph.D.

CONTACT

[email protected]

0034 626419884

Noemi Casaponsa

CONTACT

[email protected]

+34 938960025

Sponsors and collaborators

Lead sponsor

Consorci Sanitari de l'Alt Penedès i Garraf

Other

Collaborators

  • Centro de Salud Les Roquetes-Sant Pere de Ribes, Barcelona, Spain
  • Centro de Salud Sant Pere de Ribes, Barcelona, Spain
  • Centro de Salud Sitges, Barcelona, Spain
  • Centro de Salud Vilanova i la Geltrú 1 Sant Joan, Barcelona, Spain
  • Centro de Salud Vilanova i la Geltrú 2 Jaume I, Barcelona, Spain
  • Centro de Salud Vilanova i la Geltrú 3 Baix A Mar, Barcelona, Spain
  • Gerència Territorial Metropolitana Sud, Alt Penedès i Garraf, Barcelona, Spain

Registry information

Official study title

Neuropsychological Assessment Of The Non-institutionalized Oldest-Old Population. Multicenter Normative Study.

Acronym: NEUROPSIC-GR

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Aug 1, 2022
Registry last updated
Jun 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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