Neuropsychiatric Effects of Deep Brain Stimulation in Patients With Parkinson's Disease

Stimulation of the subthalamic nucleus will have effects on various aspects of neuropsychiatric function.

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Key information

Conditions

Parkinson's Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Scripps Clinic Torrey Pines

La Jolla, California, 92092, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants diagnosed with idiopathic Parkinson's disease that meet criteria for treatment of their disease with STN-DBS. Participants will be selected for this study without regard for age (provided they are older than 18), gender or ethnic background.
Participants must have undergone subthalamic nucleus DBS surgery and be receiving treatment at the Scripps Clinic in La Jolla, CA

Exclusion criteria

Patients under 18 years old.
Patients with mini-mental status scores below 26/30.
Patients with known psychiatric disease.
Patients who are too infirm, demented or dysarthric to clearly understand the consenting process, task instructions, or to communicate verbally regarding participation or non-participation.

Treatment and study plan

Stimulation of the subthalamic nucleus

Procedure

Stimulation is delivered to the subthalamic nucleus at experimentally prescribed settings.

Primary outcomes

behavioral task performance

Time frame: 1 to 2 hours

Participants will complete behavioral tasks at each of three visits to assess the effects of stimulation settings on task performance. At each research visit, behavior will be assessed beginning at 1 hour after the stimulation is adjusted to the experimental settings. Stimulation settings will be returned to each patient's treatment levels at the culmination of each visit.

Sponsors and collaborators

Lead sponsor

University of California, San Diego

Other

Collaborators

National Alliance for Research on Schizophrenia and Depression

Registry information

Important dates

Study start: 2008
Primary completion: 2014
Study completion: 2014
First posted: Mar 2, 2011
Registry last updated: Aug 2, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed