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NCT Number: NCT06911229

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Florida

Gainesville, Florida, 32611, United States

Location status: Recruiting

Location contact

Julia Choi

CONTACT

About this study

We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases;
  • chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings;
  • Age between 18 - 80 years old per the FDA data sheet for PD DBS;
  • no dementia according to the clinical diagnostic criteria for PD dementia;
  • ambulatory without the use of walking aids, or another person's assistance.

Exclusion criteria

  • other previous neurological surgery;
  • suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Treatment and study plan

Deep Brain Stimulation (DBS)

Device

Patients will receive DBS in the clinically-optimized setting.

Primary outcomes

  1. Step length rate of adaptation

    Time frame: 1 hour

    The rate of adaptation in step length asymmetry is estimated by fitting an exponential decay function to step length asymmetry over the first 100 strides in adaptation.

  2. Step length magnitude of adaptation

    Time frame: 1 hour

    The magnitude of adaptation in step length asymmetry is calculated as the mean difference in step length asymmetry between early and late adaptation.

  3. Step length after-effects

    Time frame: 1 hour

    The after-effect in step length asymmetry is calculated as the mean difference in step length asymmetry between baseline and early post-adaptation.

Study contacts

Contact information is provided by the study sponsor or research team.

Julia Choi, Ph.D.

CONTACT

[email protected]

3522941720

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 4, 2025
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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