Skip to main content
OpenTrials
Completed

NCT Number: NCT02125422

Neurophysiological Study of tDCS Effects in Healthy Volunteers

Transcranial direct current stimulation is a tool to modulate cortical excitability.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Volunteers

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Roberta Baschi

Liége, 4000, Belgium

About this study

Anodal transcranial direct currenti stimulation over visual cortex is able to decrease the thermo-nociceptive sensibility and thermonociceptive potentials, whilst cathodal transcranial direct current stimulation has the opposite effect, it decreases VEP amplitude and habituation. This neuromodulation technique is probably a tool in the prevention in episodic and chronic migraine.

The aim of the study is to study short and long term effect of tDCS over pain treshold, contact heat evoked potentials, blink reflex and visual evoked potentials in healthy volunteers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers

Exclusion criteria

  • age below 18 or above 65 years
  • personal history of recurrent headache or other neurological diseases especially seizures,
  • familial history of recurrent headache
  • child migraine equivalents (motion sickness, cyclic vomiting or recurrent abdominal pain, somnambulism etc.. . .)
  • chronic pain syndromes
  • analgesics intake at the time of recording
  • contra-indications to tDCS neurostimulation (metal prosthetics in the head or internal stimulation like a pacemaker).

Treatment and study plan

Cefaly tDCS

Device

Cefaly tDCS (transcranial direct current stimulation) is able to modify cortical excitability, in particular anodal tDCS increases it. The side effects of tDCS are minor, especially sensations of itching and scalp paresthesias.

Primary outcomes

  1. Neurophysiological mesures changes

    Time frame: up to 1 month

    Modifications in neurophysiological test after direct current stimulation

Other outcomes

  1. VEP changes

    Time frame: up to 1 month

    Evaluation of changes in latency, amplitude, slope and habituation

  2. Blink changes

    Time frame: up to 1 month

    Evaluation of changes in latency, amplitude, slope and habituation

  3. CHEPS changes

    Time frame: up to 1 month

    Evaluation of changes in latency, amplitude, slope and habituation

  4. Quantitave Sensory Testing

    Time frame: up to 1 month

    Evaluation of changes in thresholds

Sponsors and collaborators

Lead sponsor

University of Liege

Other

Registry information

Acronym: tDCSHV

Important dates

Study start
2013
Primary completion
2013
Study completion
2014
First posted
Apr 29, 2014
Registry last updated
May 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.