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Completed

NCT Number: NCT00399633

Neuropeptides in the Humane Intra- og Extracerebral Circulation.

The study aim at examining whether Sumatriptan changes the plasma values of the neuropeptides vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2 og PGF2α.

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Key information

Conditions

Healthy Brain Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Primary Migraine Migraine Disorders Nervous System Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Danish Headache Center

Glostrup, Copenhagen, Copenhagen, 2600, Denmark

About this study

The study is meant to give a better understanding of the basic mechanisms behind migraine, and a better understanding of the effects of sumatriptan on the trigemino vascular system.

The endpoints are changes in the plasma values of the neuropeptides vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2 og PGF2α.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers
  • 18-50 years,
  • 50-100 kg.
  • Fertile women must use birth control.

Exclusion criteria

  • All primary types of headache
  • Daily intake of medicine except birth control
  • Pregnancy
  • Hypertension
  • Hypotension
  • other chronic disease

Treatment and study plan

Sumatriptan

Drug

Primary outcomes

  1. Blood concentration of vasoactive intestinal polypeptide (VIP),

  2. calcitonin gene-related protein (CGRP), pituitary adenylate cyclase

  3. activating peptide (PACAP,) and the prostanoids

  4. 6-keto-PGF1α, PGE2, PGD2 and PGF2α, sampled from different

  5. venous catheters.

Sponsors and collaborators

Lead sponsor

Danish Headache Center

Other

Collaborators

  • Bispebjerg Hospital
  • Glostrup University Hospital, Copenhagen

Registry information

Official study title

Neuropeptides in the Humane Intra- og Extracerebral Circulation - in Relation to Sumatriptan in Healthy Volunteers.

Important dates

Study start
2007
Primary completion
2007
Study completion
2007
First posted
Nov 15, 2006
Registry last updated
May 14, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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