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Completed

NCT Number: NCT01615276

Neuromuscular Electrical Stimulation (NMES) and Muscle Protein Accretion (ES-PRO)

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES will be studied.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

65 year–85 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre

Maastricht, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • Age 65 - 85 years
  • 18.5 < BMI < 30 kg∙m2

Exclusion criteria

  • Type II diabetes
  • All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
  • Use of anticoagulants, blood diseases, allergy for lidocaine
  • Use of NSAIDs and acetylsalicylic acid
  • Patients suffering from PKU (Phenylketonuria)
  • Presence of implantable cardioverter defibrillator and/or pacemaker
  • Performed regular resistance type exercise in the past 6 months

Treatment and study plan

Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)

Device

One our of one-legged neuromuscular electrical stimulation (NMES)

No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMES

Device

No neuromuscular electrical stimulation (NMES) will be applied in the control leg

Primary outcomes

  1. Tracer enrichment in the muscle biopsy

    Time frame: 4 hours after protein ingestion

Secondary outcomes

  1. Fractional synthetic rate (FSR)

    Time frame: 0-4 hours after protein ingestion

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

The Effect of Neuromuscular Electrical Stimulation on Post-prandial Muscle Protein Accretion in Healthy Elderly Men

Acronym: ES-PRO

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jun 8, 2012
Registry last updated
May 31, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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