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NCT Number: NCT05487131

Neuromodulation and Fatigue

In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by up to 6 experimental sessions. Fatigability and motor function will be assessed in each test session.

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Key information

Conditions

Healthy Aging Fatigue Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Oklahoma

Norman, Oklahoma, 73071, United States

Location status: Recruiting

Location contact

Hugo Pereira, PhD

CONTACT

[email protected]

405-325-2773

About this study

This project will investigate the potential impact of an electrical current of low intensity, and applied non-invasively, on the signals that drive muscle contractions. Individuals will receive distinct types of stimulation that vary depending on the direction on the current (anodal vs cathodal) and placement of the electrodes. These conditions will be compared to a sham stimulation. The test session will be randomized in a double blind fashion, which indicates that neither participants or investigators will know the type of stimulation. Motor function and the muscle electrical activity will be quantified during each test session.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy individuals between 18 and 50 years old

Exclusion criteria

Metal implants or joint replacement. Presence of neuromuscular disease. Skin hypersensitivity.

Treatment and study plan

electrical stimulation

Behavioral

different types of low-intensity (comfortable) electrical stimulation will be used and applied in distinct locations

Primary outcomes

  1. Force

    Time frame: Each session will take approximately 2 hours (total of 4 test sessions)

    Change in force will be evaluated with a device during each test session

  2. Perception of effort

    Time frame: Each session will take approximately 2 hours (total of 4 test sessions)

    Change in perceived effort will be evaluated with visual analogue scales

  3. Muscle activation

    Time frame: Each session will take approximately 2 hours (total of 4 test sessions)

    Electromyography will be used to quantify muscle activation

Study contacts

Contact information is provided by the study sponsor or research team.

Hugo Pereira, PhD

CONTACT

[email protected]

405-325-2773

Sponsors and collaborators

Lead sponsor

University of Oklahoma

Other

Registry information

Official study title

Neuromodulation and Its Effects on Muscle Activity and Fatigue

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Aug 4, 2022
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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