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Completed

NCT Number: NCT00410618

Neurological Effects of Chemotherapy and Radiation Therapy in Patients With Colon Cancer

RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments.

PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.

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Key information

Conditions

Cognitive/Functional Effects Colonic Diseases Colonic Neoplasms Colorectal Cancer Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Long-term Effects Secondary to Cancer Therapy in Adults Neoplasms Neoplasms by Site Rectal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Arizona Cancer Center at University of Arizona Health Sciences Center

Tucson, Arizona, 85724-5024, United States

About this study

OBJECTIVES:

Primary

  • Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer.

Secondary

  • Analyze differences in cognitive measures and MRI data in these patients.
  • Correlate MRI measures with cognitive performance in these patients.

OUTLINE: Patients undergo cognitive performance assessment and MRI.

PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

DISEASE CHARACTERISTICS:

  • Diagnosis of colon cancer
  • Received chemotherapy and radiotherapy for colon cancer

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

Treatment and study plan

cognitive assessment

Procedure

Magnetic Resonance Imaging

Procedure

management of therapy complications

Procedure

Primary outcomes

  1. Nature and long-term ramifications of CNS injury as a result of cancer treatment

Secondary outcomes

  1. Differences in cognitive measures and MRI data

  2. Relationship between MRI measures and cognitive performance

Sponsors and collaborators

Lead sponsor

University of Arizona

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Neurological Effects of Chemotherapy and Radiation Treatment: Colon Cancer

Important dates

Study start
2003
Primary completion
2006
Study completion
2006
First posted
Dec 13, 2006
Registry last updated
Jul 6, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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