Neuroinflammatory Response in Patients With ICH and IVH Treated With rtPA

This study compares the neuroinflammatory response in patients with hypertensive ICH associated with IVH treated with intraventriculary applied rtPA, and the control group. The inflammatory mediator concentration is analyzed in local cerebrospinal liquor.

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Key information

Conditions

Hypertensive Intracerebral Hemorrhage Brain Diseases Brain Injuries Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Craniocerebral Trauma Inflammation Intracranial Hemorrhage, Hypertensive Intracranial Hemorrhages Intraventricular Hemorrhage Nervous System Diseases Neuroinflammatory Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Trauma, Nervous System Vascular Diseases Wounds and Injuries

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects with primary ICH with IVH
ICH score 2-4, , with origin of the hematoma in the basal ganglia and blood in the third and/or ventricle
Patient is not considered a surgical candidate by neurosurgery service

Exclusion criteria

No history of diseases or drugs that affect the immunological system.
ICH score 1 and 5
Current participation in another research drug treatment protocol
Previously known intracranial arteriovenous malformation or aneurysms
Intracerebral hematoma considered to be related to trauma
ICH is located in the pons
Blood in the subarachnoid space visualized on CT scan

Treatment and study plan

intraventricual recombinant tissue plasminogen activator application

Drug

Primary outcomes

Cytokine concentration difference between two groups

Time frame: Samples taken on day 0, day 1, day 3 and day 7.

Cytokine concentration measured from CSL

Sponsors and collaborators

Lead sponsor

University of Rijeka

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2017
Study completion: 2018
First posted: Mar 2, 2018
Registry last updated: Mar 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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