Skip to main content
OpenTrials
Completed

NCT Number: NCT03085602

Neuroimaging Studies of Smoking and Treatment

The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Smoking Cessation Behavior Health Behavior

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hoglund Brain Imaging Center, University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • smoke > 10 cigarettes per day
  • vision is normal or corrected-to-normal

Exclusion criteria

  • serious medical illness unsuitable for the MR scanner based on best clinical judgment
  • any neurologic or psychiatric disorder
  • diabetes
  • known heart disease
  • high blood pressure
  • currently taking psychotropic or cardiovascular medication
  • history of alcohol or other substance dependence or current abuse
  • risk for hazard due to magnetic fields such as metal in the body surgically or accidentally (e.g., pacemaker, cochlear implants, aneurysm clips, intravascular stents or coils, spinal shunt, injury involving bullets, shrapnel or metal implanted in their body, etc)
  • pregnancy

Treatment and study plan

Cognitive behavioral therapy

Behavioral

Therapy focused on explaining the physiological and psychological effects of nicotine. Training is focused on adherence to smoking instructions, physiological and psychological effects of nicotine, reviewing reasons for quitting, and coping with smoking urges. Smokers will be asked to begin smoking on a set schedule leading up to their quit day.

Other names: CBT

Health Education

Behavioral

Therapy that provides health education on the importance of healthy eating. Participants will be instructed to smoke as usual.

Primary outcomes

  1. Change in activation in reward processing regions of the brain

    Time frame: Change from Baseline to Week 4

Secondary outcomes

  1. Change in activation in cognitive control regions of the brain

    Time frame: Change from Baseline to Week 4

  2. Change in connectivity between reward and cognitive control regions of the brain

    Time frame: Change from Baseline to Week 4

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Registry information

Official study title

Smoking Cessation, Cognitive Control and Reward Processing: An fMRI Pilot Study

Important dates

Study start
2014
Primary completion
2019
Study completion
2019
First posted
Mar 21, 2017
Registry last updated
Apr 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.