Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging

Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain modulation. Such structures include the brainstem, hypothalamus, and orbitofrontal cortex and can be defined using functional brain imaging.

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Key information

Conditions

Migraine Brain Diseases Central Nervous System Diseases Chronic Migraine Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UCSF

San Francisco, California, 94115 & 94158, United States

About this study

Specific aims of the study include:

To determine the pattern of brain metabolism using positron emission tomography (PET) found in chronic migraine, episodic migraine and control patients.
To determine changes of resting state brain networks using magnetic resonance imaging (MRI) between patients with chronic or episodic headache and healthy volunteers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients aged 18-65

No medical contraindication.

Chronic headache group:

Patients with chronic primary headaches who are experiencing phases with background pain as well as habitual pain exacerbations.
Able to provide informed consent.
Not pregnant or planning to become so, with a pregnancy test prior to scanning.

Control group and Episodic migraine group:

Patients with episodic migraine
Able to provide informed consent.
Not pregnant or planning to become so, with a pregnancy test prior to scanning.

Exclusion criteria

Taking a migraine preventive currently or in the last fifteen days.
Known claustrophobia
Patient is pregnant, planning to be pregnant, or becomes pregnant.
Patients with metal implants.
Patients who have had a study involving radiation within the one year prior to enrolling in this study

Treatment and study plan

Primary outcomes

Pattern of brain metabolism using positron emission tomography(PET).

Time frame: Estimated to be approximately three years post baseline

Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging to determine the pattern of brain metabolism.
Changes of resting state brain networks using magnetic resonance imaging (MRI)

Time frame: Estimated to be approximately three years post baseline

Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging (MRI) To determine any changes of resting state brain networks

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Collaborators

Allergan

Registry information

Important dates

Study start: 2011
Primary completion: 2015
Study completion: 2015
First posted: Dec 4, 2012
Registry last updated: Jun 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed