Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment

This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

65 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Neurofeedback training (NF) as self-regulation method of brain activity, may be beneficial in elderly with mild cognitive impairment. In this pilot study, the investigators studied whether a sensorimotor(SMR)/theta NF training could improve cognitive performance and brain electrical activity in a sample group of elderly patients with mild cognitive impairment. Twenty participants performed an electroencephalography recording, a battery of neuropsychological tests before the neurofeedback training program (T0), following the neurofeedback training program (T1) and 1-month follow-up (T2).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of Mild Cognitive Impairment
education level of 9 years of studies minimum
righthandedness
subjective memory complaint confirmed by an informant
a Mini Mental Status Examination score >20.
preserve activity of daily living and absence of dementia.

Exclusion criteria

elderly persons who were under guardianship
resident in nursing facilities
neurological disease, psychiatric disease
and involved in another cogniitve intervention.

Treatment and study plan

SMR neurofeedback training to MCI

Behavioral

The intervention consisted to increase the synaptic strengths and sensitivity within this network. Electroencephalography signals for SMR/theta training was recorded at channel Cz according to the international 10-20 system. Theta rhythm was also recorded and, in this case, SMR was stimulated while theta waves were suppressed.A 32 channels system (EEGDigitrcak Biofeedback plus module, Inc Elmiko Medical) was used for the SMR/theta Neurofeedback training.

Other names: SMR, neurofeedback

Primary outcomes

Rey Auditory Verbal Learning test

Time frame: Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up

Assessment of verbal learning in episodic memory, evaluating the ability to encode, combine, store and long-term consolidation process.

Secondary outcomes

Relative power for delta, theta, alpha, sensorimotor and lower beta frequency bands.

Time frame: Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up

Electroencephalography was recorded and EEG power spectrum was calculated using the fast Fourier transform. The power spectral density was calculated to extract the relative power for each frequency band and estimated as a log-ratio.

Sponsors and collaborators

Lead sponsor

Fabienne Marlats

Other

Registry information

Official study title

SMR/Theta Neurofeedback Training Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment: A Pilot Study

Acronym: Neurofeedel

Important dates

Study start: 2016
Primary completion: 2018
Study completion: 2018
First posted: Feb 26, 2019
Registry last updated: Feb 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed