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Completed

NCT Number: NCT03595631

Neurodynamic Interventions for Multiple Sclerosis

A randomized, parallel-group, clinical trial will be conducted to compare the immediate effects of the inclusion of a neurodynamic intervention into a multimodal physiotherapy program on pressure pain sensitivity, pain and manual dexterity in patients with multiple sclerosis

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

César Fernández-de-las-Peñas

Alcorcón, Madrid, 28922, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a diagnosis of multiple sclerosis according to the modified McDonald criteria;
  • symptoms of paresthesia and lack of sensitivity in the upper extremity;
  • Expanded Disability Status Scale (EDSS) between 0 and 6.5 points;
  • absence of cognitive deficit.

Exclusion criteria

  • any exacerbation of multiple sclerosis during the previous 3 months;
  • previous hand surgery or steroid injections treatment in the upper extremity;
  • multiple diagnoses on the upper extremity (e.g., cervical radiculopathy);
  • cervical, shoulder, or upper extremity trauma;
  • other comorbid musculoskeletal medical conditions;
  • mini-mental state examination <25

Treatment and study plan

Physical Therapy

Other

Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week.

Physical Therapy plus Neurodynamic

Other

Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week. In addition, they will also receive bilateral nerve slider neurodynamic interventions targeting the median, ulnar and radial nerves.

Primary outcomes

  1. Changes in pressure pain sensitivity

    Time frame: Baseline and one week after the last treatment session

    Pressure pain threshold over the median, ulnar and radial nerves, second metacarpal and tibialis anterior

Secondary outcomes

  1. Changes in upper extremity pain intensity before and after the intervention

    Time frame: Baseline and one week after the last treatment session

    A Numerical Pain Rate Scale (NPRS, 0-10) will be used to record the mean and the worst intensity of pain in te upper extremity

  2. Changes in light touch detection threshold

    Time frame: Baseline and after treatmentBaseline and one week after the last treatment session

    Light touch detection threshold will be assessed with a standardized set of modified twenty von Frey hairs

  3. Changes in manual dexterity

    Time frame: Baseline and one week after the last treatment session

    Bilateral manual dexterity was bilaterally assessed using the nine-hole peg test

Sponsors and collaborators

Lead sponsor

Universidad Rey Juan Carlos

Other

Registry information

Official study title

Effects of Neurodynamic Interventions to Multimodal Physical Therapy in Patients With Multiple Sclerosis

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Jul 23, 2018
Registry last updated
Oct 22, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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