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Completed

NCT Number: NCT07181057

Neurocognitive Effects of Meal Timing in a One-Meal-a-Day Regimen

Objectives: The purpose of this study is to examine how meal timing in a one-meal-a-day (OMAD) regimen influences neurocognitive outcomes.

Methods: Twelve cognitively active participants (academics, students, software engineers) will complete three randomized OMAD conditions, consuming a standardized isocaloric meal at 08:00, 12:30, or 18:00. ERPs will be recorded during a computerized Stroop task to evaluate peak amplitudes and latencies under congruent and incongruent conditions. Resting-state EEG will be measured under eyes-open and eyes-closed conditions. Behavioral performance on the Stroop task, including reaction time and accuracy, will also be assessed.

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Key information

Conditions

Fasting State Cognitive Abilities

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Erzurum Technical University Sport Sciences Faculty

Erzurum, 25240, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male, 20 to 45 years of age

Right-handed

Normal or corrected-to-normal vision

Cognitively active individuals (academic staff, graduate students, or software/algorithm engineers)

Regular sleep-wake schedule during the week preceding the experiment

Ability to abstain from caffeine, alcohol, or psychoactive substances for at least 24 hours prior to each test session

Body mass index between 18.5 and 30 kg/m²

Exclusion criteria

History of neurological, psychiatric, metabolic, or sleep disorders

Current use of medications that affect the central nervous system

Shift work or irregular sleep patterns (verified by sleep diary)

Prior experience with one-meal-a-day dietary routines

Body mass index below 18.5 or above 30 kg/m²

Treatment and study plan

one-meal-a-day (OMAD)

Other

Arm Title: Morning Meal (08:00)

Intervention: Other: One-meal-a-day (OMAD)

Description: Participants consume a single isocaloric meal at 08:00.

Arm Title: Midday Meal (12:30)

Intervention: Other: One-meal-a-day (OMAD)

Description: Participants consume a single isocaloric meal at 12:30.

Arm Title: Evening Meal (18:00)

Intervention: Other: One-meal-a-day (OMAD)

Description: Participants consume a single isocaloric meal at 18:00.

Primary outcomes

  1. Positive Peak Amplitude of Event-Related Potentials During Stroop - Congruent Trials

    Time frame: Day 1 Morning session (09:30-11:00, pre-meal) and Day 1 Afternoon session (14:30-16:00, ~6 hours post-meal). Each participant completes three separate test days (morning, midday, evening feeding), ≥48 hours apart.

    Maximum voltage deflection (µV) within 250-450 ms after stimulus onset at CP1, CP2, Pz, P3, O1, and O2 electrodes, recorded during congruent Stroop trials using a 32-channel EEG system.

  2. Latency of Positive Peak of Event-Related Potentials During Stroop - Congruent Trials

    Time frame: Day 1 Morning session (09:30-11:00, pre-meal) and Day 1 Afternoon session (14:30-16:00, ~6 hours post-meal). Each participant completes three separate test days (morning, midday, evening feeding), ≥48 hours apart.

    Time point (ms) of maximum positive deflection within 250-450 ms after stimulus onset at CP1, CP2, Pz, P3, O1, and O2 electrodes.

Secondary outcomes

  1. Resting-State EEG Absolute Power (Eyes-Open and Eyes-Closed)

    Time frame: Day 1 Morning session (09:30-11:00, pre-meal) and Day 1 Afternoon session (14:30-16:00, ~6 hours post-meal). Each participant completes three separate test days (morning, midday, evening feeding), ≥48 hours apart.

    Broadband spectral power (µV²) recorded at CP1, CP2, Pz, P3, O1, and O2 electrodes during standardized eyes-open and eyes-closed resting-state EEG.

Sponsors and collaborators

Lead sponsor

Erzurum Technical University

Other

Registry information

Official study title

Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normal and Cold Environments: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Acronym: OMAD

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 18, 2025
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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