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NCT Number: NCT04566744

NeuroCognitive Bases of Tool Use

Tool use is considered to be the hallmark of complex cognitive adaptations that humans have achieved trough evolution, that provides an adaptive advantage to the human species. Even if nonhuman species do use tools too, human tool use is much more complex and sophisticated. If humans have special abilities for tool use, it has to be grounded in a specific neuroanatomical substrate. Humans and nonhumans share a similar prehension system located within the superior parietal lobe and the intraparietal sulcus. However, there is a human specificity: the supramarginal gyrus within the left inferior parietal lobe is unique to humans, and could play a central role in tool use. This project aims to study the neurocognitive bases of human tool use with functional Magnetic Resonance Imaging (fMRI), to precise the cognitive mechanisms through which humans are able to use tools.

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CERMEP

Bron, France

Location status: Recruiting

Location contact

Emanuelle REYNAUD, PhD

SUB_INVESTIGATOR

François OSIURAK, PhD

CONTACT

[email protected]

04 78 77 43 95 ext. +33

François OSIURAK, PhD

PRINCIPAL_INVESTIGATOR

Jordan NAVARRO, PhD

SUB_INVESTIGATOR

Yves ROSSETTI, MD

CONTACT

[email protected]

04 72 91 34 00 ext. +33

Yves ROSSETTI, MD

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To be between the ages of 18 and 65 years old
  • Having given an informed consent for the study

Exclusion criteria

  • Pregnant or breastfeeding woman
  • Persons under curators or deprived of civil rights or deprived of their freedom
  • Not being registered with the French Social Security System
  • Not able to read/write the French
  • Neurologic or psychiatric illness, known or revealed during the inclusion visit
  • Substance intake ( taking psychoactive medications or recreational drugs) on the day of the experiment
  • Noise intolerance
  • Unable to fill a questionnaire (severe cognitive troubles)
  • Not willing that their personal doctor to be informed in case of a MRI anomaly.
  • Not willing to be informed in case of MRI anomaly
  • Subjects must not have metallic or electronic implants in the body : pacemakers or pacemaker wires, open heart surgery, artificial heart valve, brain aneurysm surgery, middle ear implant, hearing aid, braces or extensive dental work, cataract surgery or lens implant, implanted mechanical or electrical device, or artificial limb or joint o foreign metallic objects in the body (bullets, pellets, shrapnel, or metalwork fragments) or current or past employment as machinists, welders or metal workers, tattoos near the head or neck regions, permanent makeup
  • Not willing to complete the study
  • Appearance of a exclusion criterion during the protocol
  • Appearance of an undesirable event preventing the completion of the protocol
  • Too great head movements (>4mm for the session)
  • Detection of artifacts in the brain images collected

Treatment and study plan

fRMI

Other

The measurements performed will be the participant's brain activity, as well as behavioral measurements associated with the tasks performed (response time, correctness of the response). Brain activity measurements will be performed on the Siemens 3T system of the MRI department of CERMEP. The subject will perform the task under study while the level of brain activity is recorded. The functional examination will be subdivided into several parts according to its total length in order to spare the subject. The total duration of MRI acquisitions will be approximately 1 hour regardless of the axis.

Primary outcomes

  1. Blood Oxygenation Level Dependent measure

    Time frame: 1 hour

    The primary outcome measure will be the Blood Oxygenation Level Dependent measure (BOLD) as permitted with functional Magnetic Resonance Imaging.This BOLD level will be collected for every voxel in the imaged brain, and at regular time intervals (TR = 3s) during the experimental session (about one hour). This is standard procedure for fMRI experiments. FMRI measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the BOLD contrast in response to an experimental condition (Ogawa, Lee, Kay, & Tank, 1990), allowing researchers to track changes in oxygen consumption on the brain and therefore brain activity. BOLD effefct is computed by assessing the different relaxation times (T1 and T2) in the brain, as T1 and T2 are different in function of regional cerebral blood flows

Study contacts

Contact information is provided by the study sponsor or research team.

François OSIURAK, PhD

CONTACT

[email protected]

04 78 77 43 95 ext. +33

Yves ROSSETTI, MD

CONTACT

[email protected]

04 72 91 34 00 ext. +33

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Collaborators

  • Université Lumière Lyon 2

Registry information

Acronym: TECHNITION

Important dates

Study start
2021
Primary completion
2027
Study completion
2027
First posted
Sep 28, 2020
Registry last updated
Jun 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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