Karolinska University Hospital (ANOVA)
Stockholm, 113 64, Sweden
NCT Number: NCT03495414
Hypersexual Disorder (HD), sometimes called "sexual addiction", is a disorder with intense sexual desires and psychological preoccupations that lead to out-of-control sexual activities with severe consequences. HD is related to higher risks of HIV infection and an important risk factor for committing sexual crimes. The prevalence of HD is 3-6% of the general population, thus, a significant burden for society. The neurobiological mechanisms behind HD are still unknown, and there is still a great need for causal treatments.
This study is aimed at identifying neurobiological and psychological mechanisms underlying HD as a basis for treatment development. The overall goal is to improve mental health, quality of life, diagnosis and treatment options for affected individuals, and to reduce the impact HD can have on society. Patients with HD will be recruited at Karolinska University Hospital in close collaboration between endocrinologists, psychologists, psychiatrists, and brain researchers at Karolinska Institutet. Cases and healthy controls will undergo brain scans (MRI), psychological and blood tests to quantify neurobiological, cognitive, and behavioral aspects of HD.
This study is directly integrated into clinical practice, can identify important targets for interventions and factors predicting treatment outcomes. This study is essential for a better understanding of HD, the improvement of treatments, and can have significant impact on the prevention of HIV infections and sexual crimes.
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Notify Me18 year–100 year
Male
Observational
Stockholm, 113 64, Sweden
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
For both patients and controls any reported medical or clinical condition known to affect brain structure and function, test performance, or associated with risks for the MRI environment will be exclusionary. The investigators will exclude for the following:
Note: There is a potentially higher prevalence of comorbidities and medication use in patients. To facilitate recruitment and study completion, the investigators may include subjects that report specific conditions at the discretion of the principle investigator. In those cases, corresponding information will be recorded in order to control for potential confounders.
We will administer neuropsychological tests assessing objective measures for
Administered questionnaires include anxiety and depression symptoms (MADRS, HADS, GAD), drug use (AUDIT, DUDIT), attention deficits (ASRS), impulsivity (BIS-11), reward seeking behavior (BIS/BAS), sexual orientation, (hyper)sexual behavior, desire and compulsivity aspects (HDSI, HBI, SCS, SDI, SIS/SES).
Blood samples will be taken for routine health assessment, measurement of sex hormonal levels, HPA-axis function test (dexamethasone suppression), and potential DNA extraction and (epi)genetic profiling.
Time frame: acquired during brain imaging experiment (MRI scan day)
Functional brain response (BOLD activity) upon presentation and anticipation of visual sexual stimuli.
Time frame: Acquired during brain imaging experiment (MRI scan day)
Measures for brain morphology (regional cortical volume, thickness, surface area, and subcortical volumes)
Time frame: Acquired during fMRI experiment (MRI scan day)
Functional connectivity
Time frame: Acquired during fMRI experiment (MRI scan day)
Structural connectivity
Time frame: Acquired during fMRI experiment (MRI scan day)
Response reaction times during fMRI task
Time frame: Acquired at brain MRI assessment day, or as close to this day as possible.
Objective measures for intelligence
Time frame: Acquired at brain MRI assessment day, or as close to this day as possible.
Objective measures for impulsivity/risk-taking
Time frame: Acquired at brain MRI assessment day, or as close to this day as possible.
Objective measures for inhibitory control
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Montgomery Asberg Depression Rating Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Adult ADHD Self-Report Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Alcohol Use Disorders Identification Test
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Drug Use Disorders Identification Test
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
General Health information
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Sexual Orientation Dimension
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Hypersexual Disorder Screening Inventory
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Sexual Compulsivity Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Hypersexual Behavior Inventory
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Sexual Inhibition/Excitation Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Hospital Anxiety and Depression Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
General Anxiety Disorder scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Bem Sex Role Inventory
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Ritvo Autism Asperger Diagnostic Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Sexual Desire Inventory
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Barratt Impulsiveness Scale
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Behavioral Inhibition/Activation System
Time frame: Assessed through an online platform (as close to MRI scan day), and/or at MRI scan day
Frequency of pornography consumption and sexual encounters.
Time frame: Assessed right before and after MRI scan
Ratings of emotions experienced in context of the fMRI task, incl. craving/desire, stimuli induced sexual arousal.
Karolinska Institutet
Other
Neurobiologisk Bakgrund Till Hypersexuell Störning
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