Skip to main content
OpenTrials
Completed

NCT Number: NCT01968512

Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder

Evaluating neurobiological disorder associated with Attention Deficit Hyperactivity Disorder (ADHD) and the contribution of transcranial direct current stimulation (tDCS) in the adaptation of inhibitory control.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Attention Deficit Hyperactivity Disorder Attention Deficit Disorder with Hyperactivity Attention Deficit and Disruptive Behavior Disorders Mental Disorders Neurodevelopmental Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Federal University of Bahia

Salvador, Estado de Bahia, 40000-000, Brazil

About this study

  • Assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs in patients with ADHD, using quantitative electroencephalography;
  • Study the contribution of transcranial direct current stimulation compared with sham in the adequacy of inhibitory control in ADHD patients through neuropsychological test-Go/No Go;
  • Assessing the efficacy of tDCS in neurobiological parameters evidenced by quantitative EEG in patients with ADHD;
  • Perform the Reconstruction of the Functional Brain Network of each subject based on the quantitative EEG data through computational and mathematical modeling;
  • Register indicators of quality of life in adults with Attention Deficit Hyperactivity Disorder through the Quality of Life Questionnaire for Adults with ADHD (AAQoL).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Signature of the informed consent;
  • Diagnosis of Attention Deficit Hyperactivity Disorder based on DSM-IV-TR and Adult Self-Report Scale (ASRS-18);
  • Adequate eyesight and hearing (or usual corrective methods such as glasses or hearing aid) that allows performing neuropsychological test and questionnaires;
  • Residents in Bahia/Brazil;
  • Over 18 years.

Exclusion criteria

  • Major psychiatric disorders such as schizophrenia and bipolar disorder;
  • Inability to understand the questionnaires used or illiterate;
  • Abuse of psychoactive substances, except nicotine and caffeine, in the last 12 months.

Treatment and study plan

Transcranial Direct Current Stimulation

Device

This technique consists in the use of low voltage electric current to increase or reduce neuronal excitability in the area stimulated. This is a non-invasive and safe intervention having infrequent and insignificant side effects characterized by mild local discomfort, itching, tingling and/or headache of short term.

Other names: tDCS

SHAM

Device

Same character of Transcranial Direct Current Stimulation but without current

Primary outcomes

  1. Quantitative electroencephalography

    Time frame: During the only day of the assessment, we will do it before (during 8 minutes) and after (during 8 minutes more) tDCS

    Quantitative electroencephalography to assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs.

Secondary outcomes

  1. Functional Brain Network

    Time frame: During the only day of the assessment, we will do it before and after tDCS

    Functional Brain Network based on the quantitative EEG data through computational and mathematical modeling. During the only day of the assessment, we will do it before (we will get this information from EEG recording during 8 minutes before do the stimulation) and after tDCS(we will get this information from EEG recording during 8 minutes after the stimulation).

Other outcomes

  1. Go/No Go test

    Time frame: During the only day of the assessment, we will do it before and after tDCS

    Neuropsychological test to assess the adequacy of inhibitory control. During the only day of the assessment, we will do it before (after 5 minutes of EEG recording, we will start the Go/No go test keeping the EEG recording for 3 minutes, and after it we will do tDCS) and after the tDCS (after 5 minutes of EEG recording, we will restart the Go/No go test keeping the EEG recording for 3 minutes).

Sponsors and collaborators

Lead sponsor

Federal University of Bahia

Other

Registry information

Official study title

Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder: Contribution of the Transcranial Direct Current Stimulation in Control Inhibitory.

Acronym: NAADHD

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Oct 24, 2013
Registry last updated
May 1, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.