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Completed

NCT Number: NCT06601751

Neurobic Exercise Program on Cognitive Abilities

This research aims to investigate the significance of a neurobic exercise program on cognitive abilities, memory retention, activities of daily living (ADL), and quality of life (QOL) among older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life.

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ZUK old home and health care center, Ghulam Haider Road, House# I-546-547, 342, 343, Faiz Building St#5, Committee Chowk, Rawalpindi.

Rawalpindi, Punjab Province, Pakistan

About this study

MCI is a condition marked by a noticeable decline in cognitive functions, it is often considered a precursor to more severe forms of dementia, making early intervention crucial. Neurobic exercises are designed to stimulate the brain through multiple senses and to create a novel thinking pattern. These exercises might include activities involving sight, smell, touch, taste, and hearing, structured over six weeks to challenge the brain with non-routine tasks that promote creative thinking and memory retention.

Neurobic exercise aims to maintain strength, flexibility, and mental health as you age.

However, most research has focused on older, healthy individuals or those with chronic conditions. Studies on elderly persons with MCI are rare, and there are limited studies on the long-term effects of improved memory function. This research aims to investigate the significance of a neurobic exercise program on cognitive abilities in older adults with mild cognitive impairment in Pakistan. It aims to find the long-term effects of a neurobic exercise program by comparing subjective and objective memory and its effects on quality of life. The findings will give insight to physiotherapists and multidisciplinary teams to improve memory retention, delay brain deterioration, and promote memory health and quality of life, making the intervention program a valuable guide.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Older adults above 60
  • Both male and female.
  • Scored <24 on the Montreal Cognitive Assessment (MoCA).
  • Scored >12 on the Modified Barthel ADL index (BAI).
  • Ability to write and read as well as communicate well, willingness to participate in the study throughout the program

Exclusion criteria

  • Neurological, musculoskeletal, psychiatric conditions, hearing loss and visual impairment.
  • Older adults with a history of allergies to the food or flowers used in the activities.

Treatment and study plan

Neurobic Exercise Program

Other

6 weeks to improve cognitive function, memory and overall brain health by introducing non-routine activities that require participants to utilise their multiple senses and remember sequences and patterns. Each activity would be performed 2-3 times/ session, for recalling the observation period set at 1 minute and at the end of the 9th week, the memory retention effect will be measured.

Traditional Brain Exercise

Other

activities like calculation or memory games. These exercises will be conducted in 2 days/week for 60-minute sessions in 6 weeks. The memory retention effect will be measured at the end of the 9th week. It is intended to be the baseline for comparing the effectiveness of a neurobic exercise program.

Primary outcomes

  1. MOCA (Montreal Cognitive Assessment)

    Time frame: 9 weeks

    The MOCA is a popular screening tool used to determine if cognitive impairment is present. It takes approximately ten minutes to complete. It evaluates visuospatial skills, attention, language, abstract reasoning, delayed recall, executive function, and orientation. MoCA is scored out of 30. A cut-off score of 26 signifies mild cognitive impairment.

  2. Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE)

    Time frame: 9 weeks

    It is used to measure subjective memory. This test measures the informant's perception of the older person's cognitive decline. Older adults are required to compare their performance today with their performance ten years ago. Informants were asked to indicate the change on a 16-item scale from 1 (much improved) to 5 (much worse).

    The cut-off scores were based on the total score divided by the number of questions (average item score range 1- 5). Lower scores indicated better subjective memory performance.

  3. Common Object Memory Test (COMT)

    Time frame: 9 weeks

    It is used to measure objective memory. The COMT was designed to assess age related memory impairments in individuals with various educational, language, and cultural backgrounds. It included repeated presentations of colour photographs containing 10 common objects (button, chair, clock, comb, cup, key, knife, leaf, scissors and umbrella) and multiple opportunities for participants to recall and recognise the original list. The total COMT scores were summed across these three steps, and the possible range was 0-90. Higher scores indicated better objective memory performance.

Secondary outcomes

  1. Modified Barthel ADL Index (BAI)

    Time frame: 9 weeks

    The Barthel Index for Activities of Daily Living is an ordinal scale used to measure a person&#39;s ability to perform ten common daily activities, including feeding, bathing, grooming, dressing, bowel and bladder control, toilet use, transfers (bed-to-chair), mobilityon level surfaces, and stair negotiation. A modified version by Collin and Wade uses a three-point scoring system (0 = unable, 1 = needs assistance, 2 = independent) with a total score ranging from 0 to 20. The assessment takes 2-5 minutes to complete.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effects of Neurobic Exercise Program on Cognitive Abilities Among Older Adults With Mild Cognitive Impairment. A Randomised Controlled Trial.

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 19, 2024
Registry last updated
Jul 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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