Neurobehavioral Mechanisms of Cocaine Choice

The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during a behavioral intervention (alternative money reinforcer) that models contingency management.

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Key information

Conditions

Cocaine Use Disorder

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Laboratory of Human Behavioral Pharmacology

Lexington, Kentucky, 40536-0086, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Recent cocaine use, otherwise healthy

Exclusion criteria

Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease

Treatment and study plan

Money

Behavioral

Three money values offered as alternatives to cocaine.

Cocaine HCl

Drug

3 mg/70 kg is available as an alternative to money.

Primary outcomes

The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative

Time frame: Choices occur across a 40 minute session

The reinforcing effects of cocaine are determined using a reinforcement learning choice task. Subjects complete trials in which they could possibly receive the available cocaine dose or money. Reinforcing effects are measured for a fixed cocaine dose when three amounts of money are available as alternatives to cocaine. Each money value is tested in a separate session.

Sponsors and collaborators

Lead sponsor

Joshua A. Lile, Ph.D.

Other

Collaborators

National Institute on Drug Abuse (NIDA)

Registry information

Important dates

Study start: 2021
Primary completion: 2025
Study completion: 2025
First posted: Mar 5, 2020
Registry last updated: Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed