Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment

The purpose of this study is to longitudinally examine neurobehavioral functioning outcomes and use of special education services in brain tumor and CNS tumor patients treated with proton radiation at MGH. Furthermore, we seek to correlate neurobehavioral data with pertinent clinical information. We anticipate better neurobehavioral functioning to be associated with use of protons (vs. photons, as reported in the literature). We also anticipate the need and utilization of special education services to be lower in brain and CNS tumor patients treated with protons (vs. photons, as reported in the literature). Lastly, we anticipate greater neurobehavioral deficits in patients whose proton radiation treatment involved the craniospinal axis compared to those who received proton radiation to the involved field.

Inclusion criteria

• Children diagnosed with brain or CNS tumors and treated with proton radiation therapy at the MGH Francis H. Burr Proton Center since September 2002
• Patients received baseline neurocognitive testing at MGH
• Patients ≤25 years at the time of diagnosis
• Tumor location in the brain or CNS
• Radiation treatment consisted of only proton radiotherapy
• No prior radiation exposure or chemotherapy

Exclusion criteria

• Patients receiving treatment with palliative intent
• Patients who do not wish to participate
• Patient is deceased at ≥1 year follow-up