Skip to main content
OpenTrials
Completed

NCT Number: NCT01297660

Neuro-urological Outcome After Spinal Cord Injury

Most patients with spinal cord injury suffer from bladder dysfunction which may - especially in the long-term - impair renal function. Improved treatment during the last decades improved life expectancy and quality of life. This study evaluates the bladder function in the long-term after spinal cord injury.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Urinary Bladder Neurogenic Dysfunction Behavior Central Nervous System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Health Behavior Male Urogenital Diseases Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Patient Acceptance of Health Care Patient Compliance Signs and Symptoms Spinal Cord Diseases Spinal Cord Injuries Trauma, Nervous System Treatment Adherence and Compliance Urinary Bladder Diseases Urinary Bladder, Neurogenic Urogenital Diseases Urologic Diseases Wounds and Injuries

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital

Zurich, Canton of Zurich, 8008, Switzerland

About this study

Bladder dysfunction is a common consequence of spinal cord injury and depends on the completeness and the level of the lesion. Patients with suprasacral injury usually suffer from neurogenic detrusor overactivity mostly combined with detrusor sphincter dyssynergia. Without adequate treatment, this adverse combination puts the upper urinary tract at risk due to high intravesical pressure often causing vesico-ureteral reflux. Based on improved therapeutic options in the last decades, life expectancy and quality of life constantly increased in spinal cord injury patients. The investigators aim to evaluate the bladder function in the long-term after spinal cord injury.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Spinal cord injury for at least 5 years
  • Neurogenic lower urinary tract dysfunction
  • Written informed consent

Exclusion criteria

  • Lower urinary tract dysfunction due to other causes than spinal cord injury

Treatment and study plan

Video-urodynamic examination

Other

Primary outcomes

  1. Urodynamic evaluation

    Time frame: 5 years after SCI, yearly thereafter (participants are followed until death)

    Max. cystometric capacity, compliance, detrusor leak point pressure

Secondary outcomes

  1. secondary complications

    Time frame: 5 years after SCI, yearly thereafter (participants are followed until death)

    recurrent tract infection, deterioration of the upper urinary tract

  2. imaging of the upper urinary tract

    Time frame: 5 years after SCI, yearly thereafter (participants are followed until death)

    videocystography, ultrasound

Sponsors and collaborators

Lead sponsor

Balgrist University Hospital

Other

Registry information

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Feb 17, 2011
Registry last updated
Dec 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.